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TRAIL 抗体

Name: TRAIL 抗体
Brand: antibodies-online
SKU: ABIN1169389
Availability: OutOfStock

This anti-TRAIL antibody is a 小鼠单克隆 antibody detecting TRAIL in WB. Suitable for 人. This Primary Antibody has been cited in 4+ publications.

(4 references)

产品编号 ABIN1169389

发货至: 中国

Quick Overview for TRAIL 抗体 (ABIN1169389)

抗原

See all TRAIL (TNFSF10) 抗体

TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This TRAIL antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

HS501

Discover our top product TNFSF10 Primary Antibody

特异性

Recognizes human TRAIL.

交叉反应

人

纯化方法

Purified from concentrated hybridoma tissue culture supernatant.

纯度

>95 % (SDS-PAGE)

免疫原

Recombinant human TRAIL.

亚型

IgG1
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 39-250) antibody
TNFSF10 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 185-281) antibody
TNFSF10 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) antibody
TNFSF10 适用: 人 FACS, Func 宿主: 小鼠 Monoclonal 2E5 unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) antibody (PE)
TNFSF10 适用: 人 FACS 宿主: 小鼠 Monoclonal 2E5 PE

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 115-287) antibody
TNFSF10 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 1-300) antibody
TNFSF10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 1-300) antibody
TNFSF10 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) antibody
TNFSF10 适用: 人 FACS 宿主: 小鼠 Monoclonal 2E5 unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (Internal Region) antibody
TNFSF10 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 40-291) antibody
TNFSF10 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

In PBS containing 10 % glycerol and 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

有效期

12 months
Luetzkendorf, Mueller, Mueller, Caysa, Nerger, Schmoll: "Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence." in: Journal of cellular and molecular medicine, Vol. 14, Issue 9, pp. 2292-304, (2010) (PubMed).

Wenger, Mattern, Penzel, Gassler, Haas, Sprick, Walczak, Krammer, Debatin, Herr: "Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors." in: Cell death and differentiation, Vol. 13, Issue 10, pp. 1740-51, (2006) (PubMed).

Huber, Fais, Iero, Lugini, Canese, Squarcina, Zaccheddu, Colone, Arancia, Gentile, Seregni, Valenti, Ballabio, Belli, Leo, Parmiani, Rivoltini: "Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape." in: Gastroenterology, Vol. 128, Issue 7, pp. 1796-804, (2005) (PubMed).

Washburn, Weigand, Grosse-Wilde, Janke, Stahl, Rieser, Sprick, Schirrmacher, Walczak: "TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 4, pp. 1814-21, (2003) (PubMed).
抗原

TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

别名

TRAIL

背景

TNF-related apoptosis-inducing ligand (TRAIL, Apo2L,CD253, TNFSF10) is a type II transmembrane protein of about 34 kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4, Apo2, CD261, TNFRSF10A), TRAIL-R2 (DR5, KILLER, TRICK2A, TRICK2B, CD262, TNFRSF10B), TRAIL-R3 (DcR1, LIT, TRID, CD263, TNFRSF10C), TRAIL-R4 (DcR2, TRUNDD, CD264, TNFRSF10D), and osteoprotegerin (OPG, OCIF, TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC). .

UniProt

P50591

途径

Apoptosis, Positive Regulation of Endopeptidase Activity