Caspase 1 p20 抗体
This anti-Caspase 1 p20 antibody (ABIN1169381) is a Mouse Monoclonal antibody detecting Caspase 1 p20 in WB, IP, IHC. Suitable for Mouse.
(57 references)Quick Overview for Caspase 1 p20 抗体 (ABIN1169381)
抗原
Caspase 1 p20
适用
小鼠
宿主
小鼠
克隆类型
单克隆
标记
This Caspase 1 p20 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
克隆位点
Casper-1
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特异性
- Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.
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交叉反应
- 小鼠
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant mouse caspase-1.
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亚型
- IgG1
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anti-Caspase 1 p20 (AA 181-280) antibody
适用: 人, 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 p20 antibody适用: 人 WB 宿主: 小鼠 Monoclonal Bally-1 unconjugated
anti-Caspase 1 p20 (AA 101-200) antibody适用: 人, 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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: "Lactic acid bacterium, Lactobacillus paracasei KW3110, suppresses inflammatory stress-induced caspase-1 activation by promoting interleukin-10 production in mouse and human immune cells." in: PLoS ONE, Vol. 15, Issue 8, pp. e0237754, (2020) (PubMed).
: "The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation." in: Cell metabolism, Vol. 32, Issue 3, pp. 468-478.e7, (2020) (PubMed).
: "An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages." in: Cell reports, Vol. 32, Issue 4, pp. 107959, (2020) (PubMed).
: "Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD." in: Life science alliance, Vol. 3, Issue 6, (2020) (PubMed).
: "CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis." in: Frontiers in medicine, Vol. 7, pp. 88, (2020) (PubMed).
: "A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling." in: Cell reports, Vol. 31, Issue 1, pp. 107466, (2020) (PubMed).
: "Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion." in: PLoS pathogens, Vol. 16, Issue 3, pp. e1008364, (2020) (PubMed).
: "Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages." in: Scientific reports, Vol. 10, Issue 1, pp. 3709, (2020) (PubMed).
: "Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome." in: Emerging microbes & infections, Vol. 9, Issue 1, pp. 278-290, (2020) (PubMed).
: "Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice." in: Nature communications, Vol. 11, Issue 1, pp. 220, (2020) (PubMed).
: "Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages." in: EMBO reports, Vol. 20, Issue 12, pp. e48109, (2020) (PubMed).
: "DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages." in: Life science alliance, Vol. 2, Issue 1, (2020) (PubMed).
: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." in: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).
: "Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration." in: Scientific reports, Vol. 10, Issue 1, pp. 2263, (2020) (PubMed).
: "Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse." in: Cellular and molecular gastroenterology and hepatology, Vol. 9, Issue 4, pp. 679-688, (2020) (PubMed).
: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." in: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).
: "Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome." in: Nature, Vol. 570, Issue 7761, pp. 338-343, (2020) (PubMed).
: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." in: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).
: "Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production." in: Cell metabolism, Vol. 29, Issue 6, pp. 1350-1362.e7, (2020) (PubMed).
: "El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes." in: Frontiers in immunology, Vol. 10, pp. 2463, (2019) (PubMed).
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: "Lactic acid bacterium, Lactobacillus paracasei KW3110, suppresses inflammatory stress-induced caspase-1 activation by promoting interleukin-10 production in mouse and human immune cells." in: PLoS ONE, Vol. 15, Issue 8, pp. e0237754, (2020) (PubMed).
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- Caspase 1 p20
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别名
- Caspase-1 p20
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背景
- Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
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UniProt
- P29452
抗原
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