Caspase 1 p20 抗体
(8 references)Quick Overview for Caspase 1 p20 抗体 (ABIN1169380)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.
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交叉反应
- 人
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant human caspase-1.
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亚型
- IgG1
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anti-Caspase 1 p20 (AA 181-280) antibody
适用: 人, 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 p20 antibody适用: 小鼠 WB, IP, IHC 宿主: 小鼠 Monoclonal Casper-1 unconjugated
anti-Caspase 1 p20 (AA 101-200) antibody适用: 人, 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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: "Platelets Fuel the Inflammasome Activation of Innate Immune Cells." in: Cell reports, Vol. 31, Issue 6, pp. 107615, (2020) (PubMed).
: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." in: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).
: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." in: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).
: "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." in: Immunity, Vol. 50, Issue 6, pp. 1401-1411.e4, (2019) (PubMed).
: "The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy." in: Molecular cell, Vol. 73, Issue 3, pp. 429-445.e7, (2019) (PubMed).
: "WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3." in: Cancer science, Vol. 108, Issue 3, pp. 520-527, (2017) (PubMed).
: "The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3." in: Cell, Vol. 171, Issue 5, pp. 1110-1124.e18, (2017) (PubMed).
: "Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells." in: Cell death and differentiation, Vol. 21, Issue 12, pp. 1914-24, (2014) (PubMed).
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: "Platelets Fuel the Inflammasome Activation of Innate Immune Cells." in: Cell reports, Vol. 31, Issue 6, pp. 107615, (2020) (PubMed).
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- Caspase 1 p20
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别名
- Caspase-1 p20
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背景
- Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
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UniProt
- P29466
抗原
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