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DDX58 抗体 (AA 201-713)

Name: DDX58 抗体 (AA 201-713)
Brand: antibodies-online
SKU: ABIN1169336
Availability: OutOfStock

Cited in 8+ publications. This 小鼠单克隆 anti-DDX58 antibody (Clone Alme-1) specifically detects DDX58 in WB, IHC 和 IP. The antibody is reactive with 人和小鼠 samples.

Immunohistochemical staining of endogenous human RIG-I in different human tissues (paraffin sections) using anti-RIG-I, mAb (Alme-1) . (DDX58 抗体 (AA 201-713))

IHC

Western blot analysis of human RIG-I in HeLa cells by using RIG-I, mAb (Alme-1) . (DDX58 抗体 (AA 201-713))

2 images

(8 references)

产品编号 ABIN1169336

发货至: 中国

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Quick Overview for DDX58 抗体 (AA 201-713) (ABIN1169336)

抗原

See all DDX58 抗体

DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

适用

人, 小鼠

宿主

小鼠

克隆类型

单克隆

标记

This DDX58 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

克隆位点

Alme-1

Discover our top product DDX58 Primary Antibody

抗原表位
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AA 201-713

特异性

Recognizes human and mouse RIG-I.

交叉反应

人, 小鼠

纯化方法

Purified from concentrated hybridoma tissue culture supernatant.

纯度

>95 % (SDS-PAGE)

免疫原

Recombinant human RIG-I (aa 201-713).

亚型

IgG1
anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 550-776) antibody
DDX58 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 1-211) antibody
DDX58 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (C-Term) antibody
Verified DDX58 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody
DDX58 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 6C1 unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 789-925) antibody
DDX58 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 4G1B6 unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (C-Term) antibody
DDX58 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 726-925) antibody
DDX58 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (N-Term) antibody
DDX58 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 200-250) antibody
DDX58 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 894-925), (C-Term) antibody
DDX58 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB8008 unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

In PBS containing 10 % glycerol and 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

有效期

12 months
Kell, Hemann, Turnbull, Gale: "RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication." in: PLoS pathogens, Vol. 16, Issue 4, pp. e1008483, (2020) (PubMed).

Moriyama, Koshiba, Ichinohe: "Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses." in: Nature communications, Vol. 10, Issue 1, pp. 4624, (2020) (PubMed).

Soonthornvacharin, Rodriguez-Frandsen, Zhou, Galvez, Huffmaster, Tripathi, Balasubramaniam, Inoue, de Castro, Moulton, Stein, Sánchez-Aparicio, De Jesus, Nguyen, König, Krogan, García-Sastre, Yoh et al.: "Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. ..." in: Nature microbiology, Vol. 2, pp. 17022, (2018) (PubMed).

Harden, Munger: "Human papillomavirus 16 E6 and E7 oncoprotein expression alters microRNA expression in extracellular vesicles." in: Virology, Vol. 508, pp. 63-69, (2017) (PubMed).

Pythoud, Rothenberger, Martínez-Sobrido, de la Torre, Kunz: "Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS." in: Journal of virology, Vol. 89, Issue 12, pp. 6240-50, (2015) (PubMed).

Weber, Gawanbacht, Habjan, Rang, Borner, Schmidt, Veitinger, Jacob, Devignot, Kochs, García-Sastre, Weber: "Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling." in: Cell host & microbe, Vol. 13, Issue 3, pp. 336-46, (2013) (PubMed).

Gack, Nistal-Villán, Inn, García-Sastre, Jung: "Phosphorylation-mediated negative regulation of RIG-I antiviral activity." in: Journal of virology, Vol. 84, Issue 7, pp. 3220-9, (2010) (PubMed).

Rebsamen, Meylan, Curran, Tschopp: "The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases." in: Cell death and differentiation, Vol. 15, Issue 11, pp. 1804-11, (2008) (PubMed).
抗原

DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

别名

RIG-I

背景

RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

UniProt

O95786

途径

Activation of Innate immune Response, Hepatitis C