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DDX58 抗体 (AA 201-713)

This anti-DDX58 antibody is a 小鼠 单克隆 antibody detecting DDX58 in WB, IHC 和 IP. Suitable for 人 和 小鼠. This Primary Antibody has been cited in 8+ publications.
产品编号 ABIN1169336
发货至: 中国

Quick Overview for DDX58 抗体 (AA 201-713) (ABIN1169336)

抗原

See all DDX58 抗体
DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

适用

  • 76
  • 40
  • 16
  • 2
  • 1
人, 小鼠

宿主

  • 69
  • 11
  • 1
小鼠

克隆类型

  • 69
  • 12
单克隆

标记

  • 42
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This DDX58 antibody is un-conjugated

应用范围

  • 67
  • 22
  • 21
  • 14
  • 14
  • 11
  • 11
  • 9
  • 7
  • 4
  • 4
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

克隆位点

Alme-1
  • 抗原表位

    • 15
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-713

    特异性

    Recognizes human and mouse RIG-I.

    交叉反应

    人, 小鼠

    纯化方法

    Purified from concentrated hybridoma tissue culture supernatant.

    纯度

    >95 % (SDS-PAGE)

    免疫原

    Recombinant human RIG-I (aa 201-713).

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    In PBS containing 10 % glycerol and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.

    有效期

    12 months
  • Kell, Hemann, Turnbull, Gale: "RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication." in: PLoS pathogens, Vol. 16, Issue 4, pp. e1008483, (2020) (PubMed).

    Moriyama, Koshiba, Ichinohe: "Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses." in: Nature communications, Vol. 10, Issue 1, pp. 4624, (2020) (PubMed).

    Soonthornvacharin, Rodriguez-Frandsen, Zhou, Galvez, Huffmaster, Tripathi, Balasubramaniam, Inoue, de Castro, Moulton, Stein, Sánchez-Aparicio, De Jesus, Nguyen, König, Krogan, García-Sastre, Yoh et al.: "Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. ..." in: Nature microbiology, Vol. 2, pp. 17022, (2018) (PubMed).

    Harden, Munger: "Human papillomavirus 16 E6 and E7 oncoprotein expression alters microRNA expression in extracellular vesicles." in: Virology, Vol. 508, pp. 63-69, (2017) (PubMed).

    Pythoud, Rothenberger, Martínez-Sobrido, de la Torre, Kunz: "Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS." in: Journal of virology, Vol. 89, Issue 12, pp. 6240-50, (2015) (PubMed).

    Weber, Gawanbacht, Habjan, Rang, Borner, Schmidt, Veitinger, Jacob, Devignot, Kochs, García-Sastre, Weber: "Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling." in: Cell host & microbe, Vol. 13, Issue 3, pp. 336-46, (2013) (PubMed).

    Gack, Nistal-Villán, Inn, García-Sastre, Jung: "Phosphorylation-mediated negative regulation of RIG-I antiviral activity." in: Journal of virology, Vol. 84, Issue 7, pp. 3220-9, (2010) (PubMed).

    Rebsamen, Meylan, Curran, Tschopp: "The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases." in: Cell death and differentiation, Vol. 15, Issue 11, pp. 1804-11, (2008) (PubMed).

  • 抗原

    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

    别名

    RIG-I

    背景

    RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

    UniProt

    O95786

    途径

    Activation of Innate immune Response, Hepatitis C
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