电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

MAVS 抗体 (AA 160-450)

This anti-MAVS antibody is a 小鼠 单克隆 antibody detecting MAVS in WB, IHC, IP 和 ICC. Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN1169132
发货至: 中国

Quick Overview for MAVS 抗体 (AA 160-450) (ABIN1169132)

抗原

See all MAVS 抗体
MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

适用

  • 46
  • 36
  • 7
  • 2
  • 1

宿主

  • 67
  • 7
小鼠

克隆类型

  • 69
  • 5
单克隆

标记

  • 41
  • 5
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This MAVS antibody is un-conjugated

应用范围

  • 66
  • 29
  • 15
  • 15
  • 13
  • 13
  • 12
  • 10
  • 7
  • 4
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

克隆位点

Adri-1
  • 抗原表位

    • 15
    • 8
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 160-450

    特异性

    Recognizes human Cardif.

    交叉反应

    纯化方法

    Purified from concentrated hybridoma tissue culture supernatant.

    纯度

    >95 % (SDS-PAGE)

    免疫原

    Recombinant human Cardif (aa 160-450).

    亚型

    IgG2b
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    In PBS containing 10 % glycerol and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.

    有效期

    12 months
  • Morikawa, Gouttenoire, Hernandez, Dao Thi, Tran, Lange, Dill, Heim, Donzé, Penin, Quadroni, Moradpour: "Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease." in: Hepatology (Baltimore, Md.), Vol. 59, Issue 2, pp. 423-33, (2014) (PubMed).

    Bellecave, Sarasin-Filipowicz, Donzé, Kennel, Gouttenoire, Meylan, Terracciano, Tschopp, Sarrazin, Berg, Moradpour, Heim: "Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 4, pp. 1127-36, (2010) (PubMed).

    Michallet, Meylan, Ermolaeva, Vazquez, Rebsamen, Curran, Poeck, Bscheider, Hartmann, König, Kalinke, Pasparakis, Tschopp: "TRADD protein is an essential component of the RIG-like helicase antiviral pathway." in: Immunity, Vol. 28, Issue 5, pp. 651-61, (2008) (PubMed).

  • 抗原

    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

    别名

    Cardif

    背景

    RIG-I (retinoic acid-inducible gene I, Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.

    UniProt

    Q7Z434

    途径

    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
You are here:
Chat with us!