MAVS 抗体 (AA 160-450)
(3 references)Quick Overview for MAVS 抗体 (AA 160-450) (ABIN1169132)
抗原
See all MAVS 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 160-450
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特异性
- Recognizes human Cardif.
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交叉反应
- 人
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant human Cardif (aa 160-450).
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亚型
- IgG2b
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anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-65) antibody
MAVS 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 34-96) antibodyMAVS 适用: 人 WB, IHC, ICC, IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (C-Term) antibodyMAVS 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-540) antibodyMAVS 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (N-Term) antibodyMAVS 适用: 人, 小鼠, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 470-519) antibodyMAVS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 146-195) antibodyMAVS 适用: 人, 小鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-30), (N-Term) antibodyMAVS 适用: 小鼠 WB 宿主: 兔 Polyclonal RB42373 unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 477-505) antibodyMAVS 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-30) antibodyMAVS 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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: "Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease." in: Hepatology (Baltimore, Md.), Vol. 59, Issue 2, pp. 423-33, (2014) (PubMed).
: "Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 4, pp. 1127-36, (2010) (PubMed).
: "TRADD protein is an essential component of the RIG-like helicase antiviral pathway." in: Immunity, Vol. 28, Issue 5, pp. 651-61, (2008) (PubMed).
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: "Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease." in: Hepatology (Baltimore, Md.), Vol. 59, Issue 2, pp. 423-33, (2014) (PubMed).
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- MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
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别名
- Cardif
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背景
- RIG-I (retinoic acid-inducible gene I, Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
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UniProt
- Q7Z434
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途径
- Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
抗原
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