Periostin 抗体 (full length)
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北京 101111
Quick Overview for Periostin 抗体 (full length) (ABIN1169103)
抗原
See all Periostin (POSTN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- anti-Periostin, mAb (Stiny-1)
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特异性
- Recognizes human and mouse periostin.
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产品特性
- Monoclonal Antibody. Recognizes human and mouse periostin. Isotype: Mouse IgG1kappa. Clone: Stiny-1. Applications: ELISA, IHC, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Full-length human periostin.
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亚型
- IgG1 kappa
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anti-Periostin (POSTN) (C-Term) antibody
POSTN 适用: 人 WB, ICC, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Periostin (POSTN) (AA 97-230) antibodyPOSTN 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Periostin (POSTN) (AA 687-716), (C-Term) antibodyPOSTN 适用: 人, 大鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB18585 unconjugated
anti-Periostin (POSTN) (AA 577-810) antibodyPOSTN 适用: 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Periostin (POSTN) (Middle Region) antibodyPOSTN 适用: 人, 小鼠, 大鼠, 豚鼠, Cow, 犬, 马, 兔, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Periostin (POSTN) (AA 193-326) antibodyPOSTN 适用: 人 IHC 宿主: 小鼠 Monoclonal POSTN-3503 unconjugated
anti-Periostin (POSTN) (AA 193-326) antibodyPOSTN 适用: 人 IHC 宿主: 小鼠 Monoclonal POSTN-3501 unconjugated
anti-Periostin (POSTN) (AA 24-836) antibodyPOSTN 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Periostin (POSTN) (N-Term) antibodyPOSTN 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Periostin (POSTN) (AA 193-326) antibodyPOSTN 适用: 人 IHC 宿主: 小鼠 Monoclonal 649M unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
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有效期
- 12 months
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: "Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells." in: PLoS ONE, Vol. 8, Issue 8, pp. e72962, (2013) (PubMed).
: "The perivascular niche regulates breast tumour dormancy." in: Nature cell biology, Vol. 15, Issue 7, pp. 807-17, (2013) (PubMed).
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- Periostin (POSTN)
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别名
- Periostin
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背景
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Alternate Names/Synonyms: Osteoblast-specific Factor 2, OSF-2, Postn
Product Description: Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.
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UniProt
- Q15063
抗原
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