BTLA 抗体
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北京 101111
Quick Overview for BTLA 抗体 (ABIN1169098)
抗原
See all BTLA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-BTLA (human), mAb (6F4)
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特异性
- Recognizes human BTLA.
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产品特性
- Monoclonal Antibody. Recognizes human BTLA. Isotype: Rat IgG1. Clone: 6F4. Applications: ELISA, FACS, FUNC (Blocking). Liquid. In PBS containing 10 % glycerol. B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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内毒素水平
- <0.001EU/μg purified protein.
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免疫原
- Ectodomain of human BTLA fused to human IgG Fc.
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亚型
- IgG1
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anti-B and T Lymphocyte Associated (BTLA) antibody
BTLA 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 31-157) antibodyBTLA 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5G1G10 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 31-157) antibodyBTLA 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7B8B4 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 179-289) antibodyBTLA 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4B12A7 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 30-183) antibodyBTLA 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 221-289) antibodyBTLA 适用: 人 WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) (C-Term) antibodyBTLA 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4D6 unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 WB, FACS, IF 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS containing 10 % glycerol.
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
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有效期
- 12 months
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: "T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7286-96, (2009) (PubMed).
: "Unconventional ligand activation of herpesvirus entry mediator signals cell survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 15, pp. 6244-9, (2009) (PubMed).
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- BTLA (B and T Lymphocyte Associated (BTLA))
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别名
- BTLA
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背景
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Alternate Names/Synonyms: B and T Lymphocyte Associated, Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3
Product Description: B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory function of HVEM. BTLA also interacts with HVEM in cis, forming a heterodimeric complex in naive T cells that inhibits HVEM-dependent signaling. The cis-interaction between HVEM and BTLA is the predominant form expressed on the surface of naive human and mouse T cells and may be important to limit trans-signaling by LIGHT, BTLA, and CD160 that are expressed in adjacent activated cells.
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UniProt
- Q7Z6A9
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途径
- Cancer Immune Checkpoints
抗原
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