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LYVE1 抗体 (AA 24-232)

Cited in 3+ publications. This anti-LYVE1 antibody is a 兔 多克隆 antibody detecting LYVE1 in WB, FACS, EIA 和 IHC (fro). Suitable for 人.
产品编号 ABIN115662
发货至: 中国
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Quick Overview for LYVE1 抗体 (AA 24-232) (ABIN115662)

抗原

See all LYVE1 抗体
LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))

适用

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宿主

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克隆类型

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多克隆

标记

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This LYVE1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 24-232

    特异性

    The antibody recognizes LYVE-1.

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Protein A Chromatography (+ his tag depleted)

    免疫原

    Recombinant Human soluble LYVE-1 (24-232) produced in insect cells. Remarks: The recombinant soluble LYVE-1 consists of amino acid 24 (Ser) to 232 (Gly) and is fused to a C-terminal His-tag (6xHis).
  • 应用备注

    ELISA (1-15 μg/mL). Western blot (1-2 μg/mL). FACS analysis (3-20 μg/mL). Immunohistochemistry on Frozen Sections (6-30 μg/mL). Please Note: For use on Paraffin Embedded Sections the affinity-purified antibody(ABIN115663) is recommended.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 溶解方式

    Restore in sterile water to a concentration of > 0.5 mg/mL.

    缓冲液

    PBS, pH 7.4 without preservatives or stabilizers

    储存液

    Without preservative

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    The lyophilized IgG is stable at 2-8 °C for one month or at -20 °C for one year from despatch. When reconstituted the antibody is stable for six weeks at 2-8 °C and at -20 °C for longer. Aliquot to

    有效期

    12 months
  • Spyridonidou, Fousteris, Antonia, Chatzianastasiou, Papapetropoulos, Nikolaropoulos: "Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase." in: Bioorganic & medicinal chemistry letters, Vol. 19, Issue 16, pp. 4810-3, (2009) (PubMed).

    Kimura, Miyashita, Suzuki, Kobayashi, Watanabe, Sonoda, Ohta, Fujiwara, Shimosegawa, Sato: "Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis." in: Blood, Vol. 113, Issue 19, pp. 4810-8, (2009) (PubMed).

    Geissler, Dashkevich, Fischer, Fries, Kuhn-Régnier, Addicks, Mehlhorn, Bloch: "First year changes of myocardial lymphatic endothelial markers in heart transplant recipients." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 29, Issue 5, pp. 767-71, (2006) (PubMed).

  • 抗原

    LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))

    别名

    LYVE-1

    背景

    LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosamino-glycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41 % similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 Molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 Molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.Synonyms: CRSBP-1, CRSBP1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, HAR, Hyaluronic acid receptor, LYVE1, Lymphatic vessel endothelial hyaluronic acid receptor 1, XLKD1

    基因ID

    10894

    NCBI登录号

    NP_006682

    UniProt

    Q9Y5Y7

    途径

    Glycosaminoglycan Metabolic Process
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