Midkine 抗体
(1 reference)Quick Overview for Midkine 抗体 (ABIN115508)
抗原
See all Midkine (MDK) 抗体适用
宿主
克隆类型
标记
应用范围
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序列
- MKHHHHHHHM KKKDKVKKGG PGSECAEWAW GPCTPSSKDC GVGFREGTCG AQTQRIRCRV PCNWKKEFGA DCKYKFENWG ACDGGTGTKV RQGTLKKARY NAQCQETIRV TKPCTPKTKA KAKAKKGKGK D
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特异性
- This antibody reacts to Midkine.
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纯化方法
- Immunoaffinity chromatography
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免疫原
- Recombinant Human Midkine produced in E.Coli
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anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 22-140) antibody
MDK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 21-143) antibodyMDK 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 22-143) antibodyMDK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 110-143), (C-Term) antibodyMDK 适用: 人, 小鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 21-143) antibodyMDK 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) antibodyMDK 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 1-143) antibodyMDK 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (Internal Region) antibodyMDK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 22-140) antibodyMDK 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 113-143), (C-Term) antibodyMDK 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB14452 unconjugated
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应用备注
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ELISA. Western Blot. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 0.05 mL of deionized water
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浓度
- 1.0 mg/mL
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缓冲液
- 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
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储存液
- Azide free
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.
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有效期
- 6 months
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: "[Surgical experience of 6 multiple primary lung cancers]" in: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 61, Issue 3, pp. 183-7, (2008) (PubMed).
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: "[Surgical experience of 6 multiple primary lung cancers]" in: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 61, Issue 3, pp. 183-7, (2008) (PubMed).
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- Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))
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别名
- Midkine
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背景
- Midkine (MK, also called neurite growth promoting factor 2, NEGF-2), a product of a retinoic acid responsive gene, is a secreted 13 kDa protein belonging to the family of heparin binding growth/differentiation factors. MK shares 45 % sequence identity with other member of this family called Pleiotrophin (HB-GAM). Midkine is composed of two domains held together by disulfide linkages. The C-terminally located domain contains two heparin binding sites and is usually responsible for midkine activity. Part of the MK activity is enhanced by dimerization of MK. Midkine has been found in vertebrates from human to zebrafish and is most strongly expresed in midgestation. In the adult MK expression is restricted. In addition to normal development, MK is also involved in the pathogenesis of diseases e.g. inflammatory diseases, human carcinomas such as esophageal, stomach, colon, pancreatic, thyroid, lung, urinary, hepatocellular, neuroblastoma, glioblastoma, Wilm´s tumor etc. High MK levels are associated with poor prognosis in some type of cancer. The increased expresion in many carcinomas indicates that MK can be applied to the diagnosis of malignancy. Midkine is expressed during the reparative stage of bone fractures, also supresses infection of certain viruses including HIV in target cells. Anti-apoptotic and cell protecting activity of midkine makes it to be a promissing in therapy.Synonyms: Amphiregulin-associated protein, MDK, MK, MK1, Midgestation and kidney protein, NEGF2, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein
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基因ID
- 4192
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NCBI登录号
- NP_001012333
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UniProt
- P21741
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途径
- RTK signaling, M Phase, Skeletal Muscle Fiber Development
抗原
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