CDK4 抗体
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北京 101111
Quick Overview for CDK4 抗体 (ABIN112138)
抗原
See all CDK4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- DCS-35 reacts specifically with CDK4 protein present predominantly in G1 phase of cell cycle. It does not cross-react with cyclins. In immunohisto-chemical application on frozen sections of head and neck carcinoma (oropharynx and hypopharynx carcinoma) DCS-156 shows distinct nuclear staining, especially in tumor areas of enhanced proliferation.
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纯化方法
- Affinity Chromatohgraphy on Protein A.
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免疫原
- Human recombinant full-length cdk4 polypeptide.
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亚型
- IgG1
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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 1-303) antibody
CDK4 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) antibodyKO Validated CDK4 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305), (C-Term) antibodyCDK4 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB03154 unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 6-295) antibodyCDK4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 211-303) antibodyCDK4 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 4F11 unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (N-Term) antibodyCDK4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) antibodyKD Validated CDK4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB745 unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303), (C-Term) antibodyCDK4 适用: 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (N-Term) antibodyCDK4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 201-303) antibodyCDK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoblotting (Western blotting). Suitable for Immunohistochemistry on Frozen and Paraffin Embedded Sections (improvedstaining after microwave treatment): 1/10Incubation Time: 1-4 h at RT or overnight at 2-8 °C.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in 1 mL distilled water.
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注意事项
- Dilute only prior to immediate use. Avoid cycles of freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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别名
- CDK4
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背景
- Cdk4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. Cdk4 is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1/S phase, which is controlled by the regulatory subunits D type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). The mutations in this gene as well as its related proteins including D type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Two alternatively spliced variants, and multiple polyadenylation sites of this gene have been reported.Synonyms: Cell division protein kinase 4, Cyclin-dependent kinase 4, PSK-J3
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基因ID
- 1019
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NCBI登录号
- NP_000066
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UniProt
- P11802
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途径
- Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size
抗原
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