Desmoplakin 抗体
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北京 101111
Quick Overview for Desmoplakin 抗体 (ABIN112137)
抗原
See all Desmoplakin (DSP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- DP 2.17 shows distinct punctate membrane staining of epithelia. It reacts with the rod fragment of Desmoplakin 1 (Mr 250,000 polypeptide of desmosomal plaques). Tested Reactivities on Cultured Cell Lines: Several Human carcinoma cell lines: MCF-7, A-431, TR-146. Bovine cells: MDBK, BMGE.
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交叉反应 （详细）
- Species reactivity (tested):Human, Bovine, Rat, Chicken and Mouse.
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纯化方法
- Protein A Affinity Chromatography
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免疫原
- Bovine Desmoplakin 1
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亚型
- IgG1
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anti-Desmoplakin (DSP) (AA 2609-2822) antibody
DSP 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyKD Validated DSP 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB5220 unconjugated Recombinant Antibody
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (AA 1-100) antibodyDSP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (Internal Region) antibodyVerified DSP 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Desmoplakin (DSP) (C-Term) antibodyDSP 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (AA 2750-2850) antibodyDSP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (AA 1900-1950) antibodyDSP 适用: 人 IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry on frozen and paraffin embedded sections after microwavetreatment (dilute 1: 10 with PBS pH 7.4). Western blot (Incubation time: 1h at RT).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 1 mL distilled water.
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缓冲液
- PBS, pH 7.4 containing 0.09 % Sodium Azide and 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
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有效期
- 6 months
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- Desmoplakin (DSP)
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别名
- Desmoplakin
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背景
- Desmosomes are intercellular junctions that form tight links between adjacent cells. Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP
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基因ID
- 1832
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NCBI登录号
- NP_001008844
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UniProt
- P15924
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途径
- Cell-Cell Junction Organization
抗原
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