我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

Cytokeratin 18 抗体

Name: Cytokeratin 18 抗体
SKU: ABIN111183
Availability: OutOfStock

Cited in 13+ publications. The 小鼠单克隆 anti-Cytokeratin 18 antibody (Clone Ks18-04) (ABIN111183) specifically detects Cytokeratin 18 in WB, IHC (p) 和 IHC (fro). The antibody is reactive with 人, 小鼠, 大鼠, 犬, Pig, Cow, Hamster, 绵羊, 斑马鱼和 Trout samples.

(13 references)

产品编号 ABIN111183

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Cytokeratin 18 抗体 (ABIN111183)

抗原

See all Cytokeratin 18 (KRT18) 抗体

Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

适用

人, 小鼠, 大鼠, 犬, Pig, Cow, Hamster, 绵羊, 斑马鱼, Trout

宿主

小鼠

克隆类型

单克隆

标记

This Cytokeratin 18 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

克隆位点

Ks18-04

Discover our top product KRT18 Primary Antibody

特异性

Ks 18.04 represents an excellent marker to discriminate simple epithelia from those of different origin. Tumors specifically detected: all adenocarcinoma, mammary carcinoma, urinary bladder carcinoma, undifferentiated carcinoma, cervix carcinoma, hepatocellular carcinoma. Polypeptide reacting: Mr 45 000 polypeptide (human keratin K18) of all simple type epithelia and basal cells of many squamous, nonepidermal epithelia. Reactivities on cultured cell lines (tested so far): HeLa and MCF-7

交叉反应（详细）

Species reactivity (tested):Human, Mouse, Rat, Bovine, Porcine, Canine, Hamster, Sheep, Fish (Trout) and Zebrafish

纯化方法

Protein A chromatography

免疫原

Human keratin K18 from HeLa cytoskeletal preparation

亚型

IgG1
anti-Keratin 18 (KRT18) (AA 53-150) antibody
KRT18 适用: 人, 小鼠, 大鼠, Pig WB, FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Keratin 18 (KRT18) antibody
KRT18 适用: 人 WB, ELISA, IHC (p), ICC, IP, ICFC 宿主: 小鼠 Monoclonal DC-10 unconjugated

anti-Keratin 18 (KRT18) antibody
KRT18 适用: 哺乳动物 WB, ELISA, IHC (p), ICC, IP, ICFC 宿主: 小鼠 Monoclonal C-04 unconjugated

anti-Keratin 18 (KRT18) (AA 238-396) antibody
KRT18 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Keratin 18 (KRT18) (AA 1-423) antibody
KRT18 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Keratin 18 (KRT18) (AA 238-396) antibody
KRT18 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal E4 unconjugated

anti-Keratin 18 (KRT18) (AA 72-380) antibody
KRT18 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Keratin 18 (KRT18) (AA 102-396) antibody
KRT18 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Keratin 18 (KRT18) antibody
KRT18 适用: 人, 犬, Cat WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal DE-K18 unconjugated

anti-Keratin 18 (KRT18) antibody
KRT18 适用: 人 WB, IHC, IF, FACS, StM, ISt 宿主: 兔 Monoclonal KRT18-2808R unconjugated Recombinant Antibody

应用备注

Western blot. Immunohistochemistry (dilute 1: 20 with PBS): suitable for cytological material, frozen andparaffin-embedded tissue (for best performance, microwave treatment is recommended). Incubation time: 1h at 37C, extended with paraffin sections (overnight at 2-8C).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
溶解方式

Restore in 1.0 mL distilled water.

缓冲液

PBS, pH 7.4, 0.09 % Sodium azide, 0.5 % BSA

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing). Dilute only prior to immediate use.

储存条件

-20 °C

储存方法

Store the antiserum at -20 °C (aliquot contents to
Zatloukal, Kufferath, Thueringer, Landegren, Zatloukal, Haybaeck: "Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies." in: PLoS ONE, Vol. 9, Issue 5, pp. e96690, (2014) (PubMed).

Trowe, Airik, Weiss, Farin, Foik, Bettenhausen, Schuster-Gossler, Taketo, Kispert: "Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter." in: Development (Cambridge, England), Vol. 139, Issue 17, pp. 3099-108, (2012) (PubMed).

Schwartz, Barker, Long, Kaufman, McCracken, Allen: "Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 6, pp. 3064-77, (2012) (PubMed).

Sharma, Cantz, Richter, Eckert, Henschler, Wilkens, Jochheim-Richter, Arseniev, Ott: "Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver." in: The American journal of pathology, Vol. 167, Issue 2, pp. 555-64, (2005) (PubMed).

Ikenouchi, Matsuda, Furuse, Tsukita: "Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail." in: Journal of cell science, Vol. 116, Issue Pt 10, pp. 1959-67, (2003) (PubMed).

Schaffeld, Knappe, Hunzinger, Markl: "cDNA sequences of the authentic keratins 8 and 18 in zebrafish." in: Differentiation; research in biological diversity, Vol. 71, Issue 1, pp. 73-82, (2003) (PubMed).

Stumptner, Fuchsbichler, Heid, Zatloukal, Denk: "Mallory body--a disease-associated type of sequestosome." in: Hepatology (Baltimore, Md.), Vol. 35, Issue 5, pp. 1053-62, (2002) (PubMed).

Bantel, Ruck, Gregor, Schulze-Osthoff: "Detection of elevated caspase activation and early apoptosis in liver diseases." in: European journal of cell biology, Vol. 80, Issue 3, pp. 230-9, (2001) (PubMed).

Gomi, Yokoyama, Fujimoto, Ikeda, Katoh, Itoh, Itohara: "Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions." in: Neuron, Vol. 14, Issue 1, pp. 29-41, (1995) (PubMed).

Leeuwenberg, Smeets, Neefjes, Shaffer, Cinek, Jeunhomme, Ahern, Buurman: "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro." in: Immunology, Vol. 77, Issue 4, pp. 543-9, (1993) (PubMed).

Bártek, Vojt?sek, Stasková, Bártková, Kerekés, Rejthar, Kovarík: "A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology." in: The Journal of pathology, Vol. 164, Issue 3, pp. 215-24, (1991) (PubMed).

Lauerová, Kovarik, Bártek, Rejthar, Vojt?sek: "Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule." in: Hybridoma, Vol. 7, Issue 5, pp. 495-504, (1989) (PubMed).

Moll, Franke, Schiller, Geiger, Krepler: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, (1983) (PubMed).
抗原

Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

别名

Cytokeratin 18

背景

Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.Synonyms: CK18, CYK18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, K18, KRT18, Keratin 18, Keratin type I cytoskeletal 18, Keratin-18

基因ID

3875

NCBI登录号

NP_000215

UniProt

P05783

途径

Apoptosis, Caspase Cascade in Apoptosis

You are here: