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CD5 抗体 (FITC)

This anti-CD5 antibody (ABIN1111108) is a Mouse Monoclonal antibody detecting CD5 in FACS. Suitable for Human.
产品编号 ABIN1111108
发货至: 中国

Quick Overview for CD5 抗体 (FITC) (ABIN1111108)

抗原

See all CD5 抗体
CD5

适用

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小鼠

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单克隆

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This CD5 antibody is conjugated to FITC

应用范围

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Flow Cytometry (FACS)

克隆位点

L17F12
  • 原理

    Anti-Hu CD5 FITC

    特异性

    The mouse monoclonal antibody L17F12 reacts with an extracellular epitope of CD5, a 67 kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes).

    交叉反应 (详细)

    Human

    纯化方法

    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    免疫原

    Human acute lymphoblastic leukemia (ALL) T cells

    亚型

    IgG2a kappa
  • 应用备注

    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

    限制

    仅限研究用
  • 溶解方式

    No reconstitution is necessary.

    缓冲液

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.
    Avoid prolonged exposure to light.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Dunphy, Tang: "The value of CD64 expression in distinguishing acute myeloid leukemia with monocytic differentiation from other subtypes of acute myeloid leukemia: a flow cytometric analysis of 64 cases." in: Archives of pathology & laboratory medicine, Vol. 131, Issue 5, pp. 748-54, (2007) (PubMed).

    Gong, Lagoo, Peters, Horvatinovich, Benz, Buckley: "Value of CD23 determination by flow cytometry in differentiating mantle cell lymphoma from chronic lymphocytic leukemia/small lymphocytic lymphoma." in: American journal of clinical pathology, Vol. 116, Issue 6, pp. 893-7, (2001) (PubMed).

    McAlister, Davis, Pfuhl, Driscoll: "NMR analysis of the N-terminal SRCR domain of human CD5: engineering of a glycoprotein for superior characteristics in NMR experiments." in: Protein engineering, Vol. 11, Issue 10, pp. 847-53, (1999) (PubMed).

    Shuster, Falletta, Pullen, Crist, Humphrey, Dowell, Wharam, Borowitz: "Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study." in: Blood, Vol. 75, Issue 1, pp. 166-73, (1990) (PubMed).

    Engleman, Warnke, Fox, Dilley, Benike, Levy: "Studies of a human T lymphocyte antigen recognized by a monoclonal antibody." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, Issue 3, pp. 1791-5, (1981) (PubMed).

  • 抗原

    CD5

    别名

    CD5

    背景

    CD5 Molecule,CD5 antigen (T1, 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells it seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (rheumatoid arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.,T1, LEU1

    基因ID

    921

    UniProt

    P06127
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