Vitronectin 抗体
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Quick Overview for Vitronectin 抗体 (ABIN1109496)
抗原
See all Vitronectin (VTN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Monoclonal antibody BV1 recognizes human vitronectin. Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. It binds to soluble vitronectin as well as to membrane bound vitronectin.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein G
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亚型
- IgG1
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anti-Vitronectin (VTN) (AA 20-199) antibody
VTN 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1G11E8 unconjugated
anti-Vitronectin (VTN) (AA 31-105) antibodyVTN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Vitronectin (VTN) (AA 364-478) antibodyVTN 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Vitronectin (VTN) (AA 19-468) antibodyVTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitronectin (VTN) antibodyVTN 适用: 人 WB, ELISA, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vitronectin (VTN) (AA 1-115) antibodyVTN 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vitronectin (VTN) antibodyVTN 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB2985 unconjugated
anti-Vitronectin (VTN) (AA 1-478) antibodyVTN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Vitronectin (VTN) (AA 1-478) antibodyVTN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- Vitronectin (VTN)
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别名
- Vitronectin
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背景
- Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. About one third of the protein molecular mass is composed of carbohydrates. Vitronectin is found in blood plasma and the extracellular matrix. Vitronectin is a multifunctional protein, since it promotes attachment and spreading of animal cells in vitro, it inhibits cytolysis by the complement C5b-9 complex, and it modulates antithrombin III-thrombin action in blood coagulation. The protein consists of three domains: the N-terminal Somatomedin B domain (1-39), a central domain with hemopexin homology (131-342) and a C-terminal domain (347-459) also with hemopexin homology. The Somatomedin B domain binds to Plasminogen Activator Inhibitor-1 (PAI-1) and is responsible for PAI-1 stabilization. Furthermore, the Somatomedin B domain can also interact with the urokinase plasminogen activator receptor (uPAR). Vitronectin-uPAR interaction is required and sufficient to initiate downstream changes in cell morphology, migration and signal transduction. High plasma levels of both PAI-1 and uPAR have been shown to correlate with a negative prognosis for cancer patients. Additionally, vitronectin is a component of platelets and is as such involved in hemostasis. Amino acid 45-47 (RGD) are capable of binding to membrane bound integrins, which serve to anchor cells to the extracellular matrix. Vitronectin in plasma is an inactive monomer form. In contrast, tissue vitronectin is an active multimeric form and is able to interact with various matrix ligands like proteoglycans and collagen. Mice with a genetic deletion of vitronectin show delayed wound healing, suggesting an important role of vitronectin in tissue remodeling after injury.Synonyms: S-protein, Serum-spreading factor, V75, VTN
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基因ID
- 7448
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NCBI登录号
- NP_000629
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UniProt
- P04004
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途径
- Autophagy, Smooth Muscle Cell Migration
抗原
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