TNC 抗体
Quick Overview for TNC 抗体 (ABIN1109217)
抗原
See all TNC 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The antibody clone EB2 reacts with the 4th and 5th fibronectin-like repeats of Human Tenascin-C polypeptides of Mr 250000 and 180000.
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交叉反应 （详细）
- Species reactivity (tested):Human, Guinea Pig and Rabbit.
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纯化方法
- Ig Fraction
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免疫原
- Purified Tenascin-C from human fetal fibroblasts. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
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亚型
- IgG1
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anti-Tenascin C (TNC) (AA 513-621) antibody
TNC 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tenascin C (TNC) antibodyTNC 适用: 人 WB, IP, IHC (p) 宿主: 小鼠 Monoclonal T2H5 unconjugated
anti-Tenascin C (TNC) (AA 49-181) antibodyTNC 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Tenascin C (TNC) (AA 175-342) antibodyTNC 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Tenascin C (TNC) (AA 1001-1100) antibodyTNC 适用: 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tenascin C (TNC) (AA 49-181) antibodyTNC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tenascin C (TNC) (AA 181-290) antibodyTNC 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tenascin C (TNC) (AA 174-621) antibodyTNC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tenascin C (TNC) antibodyTNC 适用: 人 IHC, StM 宿主: 兔 Monoclonal TNC-2981R unconjugated Recombinant Antibody
anti-Tenascin C (TNC) antibodyTNC 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TNC-3635 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.09 % Sodium Azide, 1.0 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- TNC (Tenascin C (TNC))
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别名
- Tenascin / TNC / HXB
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背景
- Tenascins were first characterized in the early 1980's. Since then hundreds of publications on tenascin in normal tissues, pathologically reactive tissues and carcinomas have been published. However, only recently more elective studies have been done. In these studies retrospective material from pathology files has been studied as well as larger fresh material collected during several years from patients. These studies have now attempted to reveal more specific points in carcinogenesis and pathological tissue reactions. It has been demonstrated that tenascin immunoreactivity in breast carcinoma cells could be indicative of metastasis and survival. Recent studies using retrospective material showed that the expression of tenascin in invasion border of early breast cancer significantly correlates with higher risk of distant metastasis. These studies have been continued now and the preliminary results clearly suggest that expression of tenascin in invasion border of early breast cancer is significantly associated with proliferative activity and higher risk of local recurrence. This result implicates a wide application for tenascin antibodies in the breast pathology. The point is that tenascin expression may suggest situations in which even small breast carcinomas may need more intensive complementary therapy (chemotherapy etc.). Recent studies have also shown that tenascin is significantly increased in airway basement membrane of asthmatics and rapidly decreases by inhaled steroid. This result suggests that tenascin expression may be used to monitor the disease status and outcome of treatment in different types of asthma.Synonyms: Cytotactin, GMEM, GP 150-225, Glioma-associated-extracellular matrix antigen, Hexabrachion, Myotendinous antigen, Neuronectin, TN-C, Tenascin-C
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基因ID
- 3371
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NCBI登录号
- NP_002151
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UniProt
- P24821
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途径
- Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development
抗原
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