SAA 抗体
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北京 101111
Quick Overview for SAA 抗体 (ABIN1108985)
抗原
See all SAA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Protein G
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免疫原
- Human SAA and Helix Pomatia Haemocyanine
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亚型
- IgG1
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anti-Serum Amyloid A (SAA) (AA 19-122) antibody
SAA 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Serum Amyloid A (SAA) (AA 19-122) antibodySAA 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Serum Amyloid A (SAA) antibodySAA 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal SAA-326 unconjugated
anti-Serum Amyloid A (SAA) (AA 20-122) antibodySAA 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Serum Amyloid A (SAA) antibodySAA 适用: 人 IHC, StM 宿主: 兔 Monoclonal SAA-2868R unconjugated Recombinant Antibody
anti-Serum Amyloid A (SAA) (AA 19-130) antibodySAA 适用: Cow WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- SAA (Serum Amyloid A (SAA))
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别名
- Serum Amyloid A Protein (SAA)
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背景
- The serum amyloid A (SAA) family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma, and constitutive SAAs (C-SAAs). Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000-fold during inflammation. Several studies have stressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations, SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumor tissues. SAA has been found to have binding sites for high density lipoproteins, calcium, laminin, and heparin/heparan-sulfate. Also adhesion motifs were identified and new functions, affecting cell adhesion, migration, proliferation and aggregation discovered. These findings emphasize the importance of SAA in various physiological and pathological processes, including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia. SAA has also a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high-density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease processes. In addition, recent experiments suggest that SAA may play a "housekeeping" role in normal human tissues. Elevated levels of SAA over time predispose to secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissue and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis.Synonyms: SAA1, SAA2
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UniProt
- P02735
抗原
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