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SAA 抗体

SAA 适用: 人 WB, IA, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal Reu86-5 unconjugated
产品编号 ABIN2191977
发货至: 中国
  • 抗原 See all SAA 抗体
    SAA (Serum Amyloid A (SAA))
    适用
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    宿主
    • 46
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    小鼠
    克隆类型
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    单克隆
    标记
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    This SAA antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    过滤
    0.2 μm filtered
    克隆位点
    Reu86-5
    Top Product
    Discover our top product SAA Primary Antibody
  • 应用备注
    For western blotting, immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • Hazenberg, Limburg, Bijzet, van Rijswijk: "A quantitative method for detecting deposits of amyloid A protein in aspirated fat tissue of patients with arthritis." in: Annals of the rheumatic diseases, Vol. 58, Issue 2, pp. 96-102, (1999) (PubMed).

    Wilkins, Gallimore, Tennent, Hawkins, Limburg, van Rijswijk, Moore, Pepys: "Rapid automated enzyme immunoassay of serum amyloid A." in: Clinical chemistry, Vol. 40, Issue 7 Pt 1, pp. 1284-90, (1994) (PubMed).

  • 抗原
    SAA (Serum Amyloid A (SAA))
    别名
    Serum Amyloid A (SAA 产品)
    别名
    PIG4 antibody, SAA antibody, SAA2 antibody, TP53I4 antibody, zgc:103580 antibody, saa antibody, SAA1 antibody, Saa-1 antibody, Saa2 antibody, serum amyloid A1 antibody, serum amyloid A antibody, serum amyloid A protein antibody, serum amyloid A-3 antibody, HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 antibody, serum amyloid A2 antibody, serum amyloid A 1 antibody, SAA1 antibody, saa antibody, LOC476879 antibody, SAA antibody, SAA3 antibody, HPS5 antibody, SAA2 antibody, Saa1 antibody, LOC100270725 antibody
    背景
    The serum amyloid A (SAA) family comprises a number of differentially expressed apolipoproteins, acute- phase SAA1 and SAA2, the former being the major component in plasma, and constitutive SAAs (C- SAAs). Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000-fold during inflammation. Several studies have stressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations, SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumor tissues. SAA has been found to have binding sites for high density lipoproteins, calcium, laminin, and heparin/heparan-sulfate. Also adhesion motifs were identified and new functions, affecting cell adhesion, migration, proliferation and aggregation discovered. These findings emphasize the importance of SAA in various physiological and pathological processes, including inflammation, atherosclerosis, thrombosis, AA- amyloidosis, rheumatoid arthritis, and neoplasia. SAA has also a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high-density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease processes. In addition, recent experiments suggest that SAA may play a "housekeeping" role in normal human tissues. Elevated levels of SAA over time predispose to secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissue and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis. The antibody is raised against human SAA and Helix Pomatia Haemocyanine. It reacts with SAA-1 type.
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