PTK7 抗体 (N-Term)
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Quick Overview for PTK7 抗体 (N-Term) (ABIN1108790)
抗原
See all PTK7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody reacts specifically with Human 112 kDa CCK-4.
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交叉反应 (详细)
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Species reactivity (expected):Mouse and Chicken.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Synthetic peptide derived from Human N-terminal region of CCK-4
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in distilled water.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer
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- PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))
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别名
- PTK7 / CCK4
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背景
- PTK7 is a member of the receptor tyrosine kinase family otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7
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基因ID
- 5754
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NCBI登录号
- NP_002812
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途径
- RTK signaling, Tube Formation
抗原
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