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PROS1 抗体

This anti-PROS1 antibody is a 大鼠 单克隆 antibody detecting PROS1 in WB. Suitable for 人.
产品编号 ABIN1108756
发货至: 中国

Quick Overview for PROS1 抗体 (ABIN1108756)

抗原

See all PROS1 (PROS) 抗体
PROS1 (PROS) (Protein S (PROS))

适用

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宿主

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大鼠

克隆类型

  • 76
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单克隆

标记

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This PROS1 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

PS7
  • 特异性

    Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. Allows specific detection of cells carrying PS by flow cytometry.

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Affinity C Chromatography on Protein G

    亚型

    IgG2a
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.02 % Sodium Azide, 0.1 % BSA

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store undiluted at 2-8 °C.
  • 抗原

    PROS1 (PROS) (Protein S (PROS))

    背景

    In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain.Synonyms: PROS, Vitamin K-dependent protein S

    基因ID

    5627

    NCBI登录号

    NP_000304

    UniProt

    P07225
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