PRTN3 抗体
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北京 101111
Quick Overview for PRTN3 抗体 (ABIN1108719)
抗原
See all PRTN3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein G
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免疫原
- A crude granule extract
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亚型
- IgG1
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anti-Proteinase 3 (PRTN3) (AA 71-247) antibody
PRTN3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proteinase 3 (PRTN3) (AA 88-98) antibodyVerified PRTN3 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Proteinase 3 (PRTN3) (AA 24-249) antibodyPRTN3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proteinase 3 (PRTN3) (AA 1-170) antibodyPRTN3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Proteinase 3 (PRTN3) (AA 228-256), (C-Term) antibodyPRTN3 适用: 人 WB 宿主: 兔 Polyclonal RB40945 unconjugated
anti-Proteinase 3 (PRTN3) (AA 1-256) antibodyPRTN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Proteinase 3 (PRTN3) (AA 1-256) antibodyPRTN3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Proteinase 3 (PRTN3) antibodyPRTN3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Proteinase 3 (PRTN3) (AA 28-170), (pArg3) antibodyPRTN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Proteinase 3 (PRTN3) (AA 139-248) antibodyPRTN3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- PRTN3 (Proteinase 3 (PRTN3))
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别名
- PR3 / C-ANCA
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背景
- PR3 is a major antigen recognized by autoantibodies directed against cytoplasmic proteins of neutrophilic granulocytes and monocytes (called anti-neutrophil cytoplasmic autoantibodies (ANCA)). ANCA are able to activate primed neutrophils to produce oxygen radicals and release lytic enzymes, including PR3. Proteinase 3 (PR3) was identified as the target antigen of ANCA in Wegener's granulomatosis (WG). ANCA directed against PR3 (PR3-ANCA) can interfere with the binding of PR3 to its physiological inhibitor alpha1-antitrypsin (alpha1-AT) and with the proteolytic activity of PR3. At the site of inflammation, PR3 can cleave the PR3-ANCA complex between these inhibiting ANCA and PR3 itself, leaving active PR3. Autoantibodies to PR3 are potent activators of the 5-lipoxygenase pathway in primed human neutrophils. Extracellular free arachidonic acid, as present at an inflammatory focus, synergizes with such autoantibodies to evoke full-blown lipid mediator generation, granule secretion and respiratory burst. Proteinase 3 (PR3) is a neutral serine proteinase, which is localized in the azurophilic granules of neutrophils and in granules of monocytes and can be detected in the membrane of secretory vesicles. PR3 degrades a number of extracellular matrix proteins such as elastin and inactivates human C1 inhibitor. Membrane-associated PR3 is also able to activate caspase-3 without triggering apoptosis of neutrophils, which is possibly a neutrophil survival mechanism. In addition, PR3 is involved in myeloid differentiation and is, therefore, also called myeloblastin.Synonyms: AGP7, Leukocyte proteinase 3, MBN, Myeloblastin, NP-4, Neutrophil proteinase 4, P29, PR-3, PRTN3, Proteinase 3, Wegener autoantigen
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UniProt
- P24158
抗原
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