GRIN1/NMDAR1 抗体 (N-Term)
Quick Overview for GRIN1/NMDAR1 抗体 (N-Term) (ABIN1108469)
抗原
See all GRIN1/NMDAR1 (GRIN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects NMDA Receptor 1 (N-term). No cross reactivity with other proteins.
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交叉反应 （详细）
- Species reactivity (tested):Human, rat, mouse
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminal of human NMDAR1 .Remarks: Sequence is identical to the related rat and mouse sequence.
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亚型
- IgG
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 600-700) antibody
GRIN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (Internal Region) antibodyVerified GRIN1 适用: 人, 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (C-Term) antibodyGRIN1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (pSer890) antibodyGRIN1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibodyGRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (HRP)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 HRP
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (FITC)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 FITC
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (Biotin)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 Biotin
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (PE)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 PE
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (APC)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 APC
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
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别名
- NMDA Receptor 1
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背景
- The NMDA receptor (NMDAR) is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. The gene is a candidate for the site of the mutation in torsion dystonia. The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.Synonyms: GRIN1, Glutamate [NMDA] receptor subunit zeta-1, NMDAR1
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基因ID
- 2902
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NCBI登录号
- NP_000823
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UniProt
- Q05586
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途径
- Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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