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GRIN1/NMDAR1 抗体 (N-Term)

Name: GRIN1/NMDAR1 抗体 (N-Term)
SKU: ABIN1108469
Availability: OutOfStock

GRIN1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

NMDAR1 Polyclonal Antibody (GRIN1/NMDAR1 抗体 (N-Term))

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产品编号 ABIN1108469

发货至: 中国

Datasheet as PDF

抗原 See all GRIN1/NMDAR1 (GRIN1) 抗体

GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
抗原表位
37

27

21

16

15

7

5

5

5

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
149

141

112

8

4

3

3

3

2

1

1

1

1
人, 大鼠, 小鼠
宿主
154

40

1

1
兔
Compatible Secondaries
克隆类型
147

49
多克隆
标记
100

10

7

6

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2
This GRIN1/NMDAR1 antibody is un-conjugated
应用范围
145

70

47

41

40

27

22

20

16

13

10

4

3

3

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

特异性

This antibody detects NMDA Receptor 1 (N-term). No cross reactivity with other proteins.

交叉反应（详细）

Species reactivity (tested):Human, rat, mouse

纯化方法

Immunogen affinity purified

免疫原

A synthetic peptide corresponding to a sequence at the N-terminal of human NMDAR1 .Remarks: Sequence is identical to the related rat and mouse sequence.

亚型

IgG

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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (C-Term) antibody
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (pSer890) antibody
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (HRP)
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (Biotin)
GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 Biotin

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (FITC)
GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 FITC

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (PerCP)
GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 PerCP

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (PE)
GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 PE

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
溶解方式

0.2 mL of distilled water will yield a concentration of 500 μg/mL.

缓冲液

5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

储存液

Sodium azide, Thimerosal (Merthiolate)

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
抗原

GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

别名

NMDA Receptor 1 (GRIN1 产品)

背景

The NMDA receptor (NMDAR) is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. The gene is a candidate for the site of the mutation in torsion dystonia. The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.Synonyms: GRIN1, Glutamate [NMDA] receptor subunit zeta-1, NMDAR1

基因ID

2902

NCBI登录号

NP_000823

UniProt

Q05586

途径

Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity