MMP2 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for MMP2 抗体 (C-Term) (ABIN1108262)
抗原
See all MMP2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- This antibody detects MMP-2 (C-term).
-
交叉反应 (详细)
- Species reactivity (tested):Human, mouse, rat
-
纯化方法
- Immunogen affinity purified
-
免疫原
- A synthetic peptide corresponding to a sequence at the C-terminal of human MMP2 .Remarks: Seqence is identical to the related rat sequence.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
溶解方式
- 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
缓冲液
- 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
-
储存液
- Sodium azide, Thimerosal (Merthiolate)
-
注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
-
-
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
-
别名
- MMP-2
-
背景
- Matrix metalloproteinase-2 (MMP2) is a Type IV collagenase, 72-kD, which is also known as gelatinase1 and is a member of a group of secreted zinc metalloproteases. The MMP2 gene is 17 kb long with 13 exons varying in size from 110 to 901 bp and 12 introns ranging from 175 to 4,350 bp 3, located within a region of human chromosome 16q13. In addition,The extra exons encode the amino acids of the fibronectin-like domain which has so far been found in only the 72-and 92- kDa type IV collagenase. MMP2,which has a critical role in the binding of progelatinase A and TIMP4 via the C-terminal hemopexin-like domain (C domain), is functionally associated on the surface of angiogenic blood vessels. NOT only is a likely effector of endometrial menstrual breakdown4, MMP2 is also effector and regulator of the inflammatory response. Moreover, MMP2 could be helpful in diagnosing Takayasu arteritis.Synonyms: 72 kDa gelatinase, 72 kDa type IV collagenase, CLG4A, Gelatinase A, MMP2, Matrix metalloproteinase-2, TBE-1
-
基因ID
- 4313
-
NCBI登录号
- NP_001121363
-
UniProt
- P08253
-
途径
- Activation of Innate immune Response
抗原
-