LY96 抗体
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北京 101111
Quick Overview for LY96 抗体 (ABIN1108190)
抗原
See all LY96 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts with soluble MD-2 (sMD-2) and the sMD-2/Toll-like receptor 4 (TLR4, CD284) complex. It reacts with both the monomeric and the polymeric form of sMD-2.
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无交叉反应
- 小鼠
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Protein G
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免疫原
- Baculovirally expressed His-tagged human MD-2
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亚型
- IgG1
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anti-Lymphocyte Antigen 96 (LY96) (AA 16-160) antibody
LY96 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 19-130) antibodyLY96 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 19-160) antibodyLY96 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 1-160) antibodyLY96 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 1-160) antibodyLY96 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 19-160) antibodyLY96 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 86-135) antibodyLY96 适用: 人, 小鼠, 大鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 96 (LY96) (AA 2-160) antibodyLY96 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 9F1B1 unconjugated
anti-Lymphocyte Antigen 96 (LY96) (Center) antibodyLY96 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- LY96 (Lymphocyte Antigen 96 (LY96))
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别名
- MD-2
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背景
- TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomer and multimers. Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representing differentially glycosylated forms. Unlike TLR4, sMD-2 binds directly LPS without the need of soluble CD14 (sCD14). However, LPS-MD-2 interactions are increased when LPS is pretreated with CD14. Only monomeric sMD-2 is biologically active and able to associate with TLR4 and LPS. sMD-2 circulates in plasma of healthy individuals as a non-active, polymeric protein. In septic plasma, the total amount of sMD-2 was strongly elevated and contained both sMD-2 polymers and monomers. Soluble MD-2 is proposed to be an important mediator of organ inflammation during sepsis. During experimental human endotoxemia, the monomeric and total sMD-2 content in plasma increased with the kinetics of an acute phase protein. This parallels enhanced TLR4 costimulatory activity. In vitro studies revealed that sMD-2 release appears to be restricted to endothelial and dendritic cells.Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2
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基因ID
- 23643
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NCBI登录号
- NP_001182726
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UniProt
- Q9Y6Y9
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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