MBP/MBL 抗体
This anti-MBP/MBL antibody is a 大鼠 单克隆 antibody detecting MBP/MBL in WB, IHC (fro), EIA 和 IF. Suitable for 小鼠.
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Quick Overview for MBP/MBL 抗体 (ABIN1108115)
抗原
See all MBP/MBL 抗体
MBP/MBL
(Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))
适用
小鼠
宿主
大鼠
克隆类型
单克隆
标记
This MBP/MBL antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunofluorescence (IF)
克隆位点
14D12
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交叉反应 （详细）
- Species reactivity (tested):Mouse
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纯化方法
- Protein G
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免疫原
- Purified MBL-C
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亚型
- IgG2a
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anti-Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL) (AA 31-130) antibody
MBP/MBL 适用: 人, 大鼠 ICC, IHC (fro), ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL) antibodyMBP/MBL 适用: 人, 小鼠, 大鼠, Cow, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))
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别名
- Mannan Binding Protein
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背景
- Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
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基因ID
- 17195
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NCBI登录号
- NP_034906
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UniProt
- P41317
抗原
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