Interferon gamma 抗体 (PE)
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- 抗原 See all Interferon gamma (IFNG) 抗体
- Interferon gamma (IFNG)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Interferon gamma antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF)
- 特异性
- The antibody detects human IFN-gamma, a 20-25 kDa glycoprotein expressed by subsets of T cells and NK cells, that have been stimulated by antigens or mitogens (1-4). Other species not tested.
- 纯化方法
- Affinity chromatography
- 克隆位点
- 45-14
- 亚型
- IgG1
- Top Product
- Discover our top product IFNG Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
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- 抗原
- Interferon gamma (IFNG)
- 别名
- IFNG / Interferon gamma (IFNG 产品)
- 背景
- The immune system reacts to a pathogen by activation of balanced network of the humoral and cellular immune responses. Subsequently the activated condition of the immune system will, after the elimination of the pathogen, be down-regulated to a balanced situation again. Control of the immune response requires efficient communication between the different cells involved in this response. This interaction is provided by cell/cell contact and by a complex array of mediators. Among these mediators cytokines, soluble factors produced by these cells, play an important role. Cytokines can act on other cells locally or distantly, but can be even auto regulating. Cytokines can behave stimulatory or inhibitory, or can even perform both activities, depending on the (pre)activation stage of the target cell. (3, 4) IFN-gamma has antiviral activity and multiple immunoregulatory functions such as upregulation of MHCClass I antigens on monocytes/macrophages and specific adhesion molecules (e.g. ICAM1 and VCAM1) on endothelial cells. IFN-gamma enhances IgG production by activated B cells, displays chemotactic activities, and plays a role in induction of inflammation.Synonyms: IFN-gamma, gamma IFN
- 基因ID
- 3458
- NCBI登录号
- NP_000610
- UniProt
- P01579
- 途径
- Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy
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