HLA B7 抗体
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Quick Overview for HLA B7 抗体 (ABIN1107562)
抗原
See all HLA B7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody clone EP-4 recognizes the HLA-B27 cell surface antigen on Human cells. Since EP-4 recognizes the HLA-B27 antigen, it may be used to HLA type human lymphoctyes. Approximately 60 % of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in Human lymphocytes. Monoclonal antibody EP-4 recognizes the HLA-B27 antigen expressed on individuals with this HLA haplotype.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Purified
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免疫原
- Native purified from lymphocytes of HLA-B27 individual.
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亚型
- IgM
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anti-HLA Class I B7 Alpha (HLA B7) antibody (PE)
HLA B7 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal BB7-1 PE
anti-HLA Class I B7 Alpha (HLA B7) antibodyHLA B7 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal BB7-1 unconjugated
anti-HLA Class I B7 Alpha (HLA B7) antibody (PE)HLA B7 适用: 人, Cynomolgus FACS 宿主: 小鼠 Monoclonal BB7-1 PE
anti-HLA Class I B7 Alpha (HLA B7) antibody (FITC)HLA B7 适用: 人, Cynomolgus FACS 宿主: 小鼠 Monoclonal BB7-1 FITC
anti-HLA Class I B7 Alpha (HLA B7) antibodyHLA B7 适用: 人, Cynomolgus FACS 宿主: 小鼠 Monoclonal BB7-1 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or -20 °C for longer.
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- HLA B7 (HLA Class I B7 Alpha (HLA B7))
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背景
- HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been describedSynonyms: B-7 alpha chain, HLA class I histocompatibility antigen, HLAB, MHC class I antigen B7
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基因ID
- 3106
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NCBI登录号
- NP_005505
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UniProt
- P01889
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途径
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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