Desmoplakin 抗体
Quick Overview for Desmoplakin 抗体 (ABIN1106984)
抗原
See all Desmoplakin (DSP) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Reacts with Human 331 kDa Desmoplakin.
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纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Synthetic peptide derived from an internal domain of Human DP
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anti-Desmoplakin (DSP) (AA 2609-2822) antibody
DSP 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (AA 1-100) antibodyDSP 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (Internal Region) antibodyVerified DSP 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Desmoplakin (DSP) (C-Term) antibodyDSP 适用: 人, 小鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (AA 2750-2850) antibodyDSP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in distilled water.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer
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- Desmoplakin (DSP)
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别名
- Desmoplakin
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背景
- Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP
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基因ID
- 1832
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NCBI登录号
- NP_001008844
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途径
- Cell-Cell Junction Organization
抗原
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