Desmoglein 2 抗体 (Extracellular Domain)
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Quick Overview for Desmoglein 2 抗体 (Extracellular Domain) (ABIN1106982)
抗原
See all Desmoglein 2 (DSG2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Extracellular Domain
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特异性
- The monoclonal antibody 6D8 recognizes the extracellular domain of human desmoglein-2. Does not cross react with desmoglein-1 and desmoglein-3.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Protein G
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免疫原
- Extracellular EC4 domain
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Desmoglein 2 (DSG2)
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别名
- Desmoglein-2
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背景
- Desmogleins and desmocollins are members of the cadherin family of transmembrane proteins that together make up the core of the desmosome, a structure that provides transmembrane strength to tissues undergoing mechanical stress. The desmosomal cadherins, desmogleins and desmocollins, mediate calcium-dependent cell-cell adhesion by forming homotypic and heterotypic interactions with one another. The multiprotein desmosomal complex also includes the cytoplasmic desmosomal plaque proteins plakoglobin, phakophilins, and desmoplakin, which bind to the intracellular domain of the desmogleins and function to anchor the keratin intermediate filament network to site of cell-cell contacts.Synonyms: CDHF5, Cadherin family member 5, DSG2, HDGC
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基因ID
- 1829
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NCBI登录号
- NP_001934
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UniProt
- Q14126
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途径
- Cell-Cell Junction Organization
抗原
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