CR1L 抗体 (FITC)
This anti-CR1L antibody is a 小鼠 单克隆 antibody detecting CR1L in WB, IHC (fro), Func, IF 和 EIA. Suitable for 大鼠.
Quick Overview for CR1L 抗体 (FITC) (ABIN1106830)
抗原
See all CR1L 抗体
CR1L
(Complement Component (3b/4b) Receptor 1-Like (CR1L))
适用
大鼠
宿主
小鼠
克隆类型
单克隆
标记
This CR1L antibody is conjugated to FITC
应用范围
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
克隆位点
TLD-1C11
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特异性
- This antibody reacts with rat-complement regulator Crry.
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交叉反应 （详细）
- Species reactivity (tested):Rat
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纯化方法
- Potein G
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免疫原
- Rat microglial cells
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亚型
- IgG1
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anti-Complement Component (3b/4b) Receptor 1-Like (CR1L) (AA 51-150) antibody
CR1L 适用: 小鼠 WB, IF (cc), IF (p), IHC (fro), ELISA, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component (3b/4b) Receptor 1-Like (CR1L) (AA 57-106) antibodyCR1L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))
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别名
- CR1L / CRRY
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背景
- Complement comprises a system of soluble serum proteins that, upon activiation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to be protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Furthermore the rat analogues of DAF, MCP and CD59 have been characterized. Rats and mice express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). In rats there are two isoforms of Crry, with six or seven short consensus repeats (SCR), encoding 65-70 and 75-85 kDa proteins, respectively, which are both transmembrane anchored. Although Crry has the functional properties of both DAF and MCP, it does not replace them. All rat blood cells express Crry whereas approximately 37 and 39 % of the rat T cells express respectively DAF and CD59. Studies in rat revealed that despite lacking DAF and CD59, these double-negative rat T cells were not more susceptible to homologous complement lysis than cells that expressed both DAF and CD59. However, blocking of the only other known rat complement regulator, Crry, enhanced lysis only at the double-negative cells. In rats, Crry exerts powerful control in the activation pathways where it acts both as a cofactor and as a decay accelerator to inactivate convertases. Crry has been succesfully expressed and refolded in bacteria. The refolded protein has full-complement regulatory activity in vitro, and has been applied in rat models of arthritis and other inflammatory diseases.Synonyms: Antigen 5I2, Complement component receptor 1-like protein, Complement regulatory protein Crry
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基因ID
- 54243
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NCBI登录号
- NP_001005265
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UniProt
- Q63135
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途径
- Complement System
抗原
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