Complement Factor B 抗体
Quick Overview for Complement Factor B 抗体 (ABIN1106809)
抗原
See all Complement Factor B (CFB) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognizes human complement Factor B/Ba.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Purified
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亚型
- IgG1
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anti-Complement Factor B (CFB) (AA 80-420) antibody
CFB 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) (AA 474-590) antibodyCFB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) (AA 34-159) antibodyCFB 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) antibodyCFB 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) antibodyCFB 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) (AA 26-751) antibodyCFB 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) antibodyCFB 适用: 人 IHC (p), ID 宿主: 山羊 Polyclonal unconjugated
anti-Complement Factor B (CFB) (AA 35-160) antibodyCFB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) (AA 301-400) antibodyCFB 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Factor B (CFB) (AA 32-157) antibodyCFB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- Complement Factor B (CFB)
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别名
- Complement Factor B
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背景
- Factor B is an acute-phase protein. Levels of factor B increase during inflammation. Complement factor B is a single- chain molecule of 764 amino acids (MW of 90 kD), including a leader peptide of 25 amino acids. Factor B provides the catalytic subunit of the C3/C5 convertases of the alternative complement pathway. Assembly of the C3 convertase (C3bBb) requires binding of factor B to C3b (C3.H2O) and factor D-mediated cleavage of bound factor B resulting in the release of Ba (MW 33 kD). The C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60 kD) is the serine protease element of this convertase. After cleavage of C3, the C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the alternative pathway of complement activation than Ba as impaired renal filtration does directly influence Ba levels. Whereas Bb is elevated 2.2-fold in chronic renal failure (CRF) patients, plasma concentrations of Ba are 8.4-fold higher in CRF and 16-fold higher in end-stage renal disease (ESRD) patients compared to normals.In addition to complement activation, factor B fragments participate in other immunological functions.Synonyms: BF, BFD, C3/C5 convertase, CFB, Glycine-rich beta glycoprotein, PBF2, Properdin factor B
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基因ID
- 629
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NCBI登录号
- NP_001701
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UniProt
- P00751
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途径
- Complement System, Proton Transport, Ribonucleoside Biosynthetic Process
抗原
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