COL2 抗体
Quick Overview for COL2 抗体 (ABIN1106745)
抗原
See all COL2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The monoclonal antibody CIICI reacts with the C1 epitope (triple helical position 358-364) of collagen type II. It has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody CIIC1 is cross reactive with rat, bovine, chicken and human CII.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat chicken, bovine
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纯化方法
- Protein G
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亚型
- IgG2a
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anti-Collagen, Type II (COL2) (AA 1201-1300) antibody
COL2 适用: 人, 小鼠, 大鼠, 兔, 豚鼠 WB, ELISA, IHC (p), IHC (fro), FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) antibodyCOL2 适用: 人 ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Collagen, Type II (COL2) (N-Term) antibodyCOL2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) (AA 1401-1487) antibodyCOL2 适用: 人, 大鼠, 兔 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) (AA 101-150) antibodyCOL2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) antibody (Biotin)COL2 适用: 人 ELISA 宿主: 山羊 Polyclonal Biotin
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- COL2 (Collagen, Type II (COL2))
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别名
- Collagen Type II
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背景
- Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA).Synonyms: COL2, Collagen II
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基因ID
- 1280
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NCBI登录号
- NP_001835
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UniProt
- P02458
抗原
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