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CD5 抗体 (FITC)

This anti-CD5 antibody is a 小鼠 单克隆 antibody detecting CD5 in FACS 和 IF. Suitable for 人.
产品编号 ABIN1106440
发货至: 中国

Quick Overview for CD5 抗体 (FITC) (ABIN1106440)

抗原

See all CD5 抗体
CD5

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD5 antibody is conjugated to FITC

应用范围

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Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

MCD5
  • 特异性

    MCD5 recognizes a 67 kDa antigen on human T cells. Other species not tested.

    纯化方法

    Affinity chromatography

    亚型

    IgG2b
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store the antibody undiluted at 2-8 °C. This product is photosensitive and should be protected from light.
  • 抗原

    CD5

    别名

    CD5

    背景

    CD5 appears to be a relatively late marker during B cell differentiation. CD5 expression is thought to be absent on surface Ig negative B-lineage cells but appears on IgM+ cells in both fetal liver and bone marrow. It co-precipitates with the T cell receptor and, in particular with Lck. A role for CD5 in signal transduction is postulated based on stimulatory effects of CD5 monoclonal antibodies. CD5 antigen is phosphorylated on tyrosine residues on T cell activation. There is evidence that CD5 plays a role in thymocyte selection, as well as a role in cell-cell recognition. Recently CD5 on B cells has been shown to be an endogenous ligand selective for B-cell surface IgFR (framework region) sequences. Interaction of surface Ig with CD5, other endogenous antigens or (in mucosal sites) exogenous superantigens can provide B cells with continual stimulation and might prevent their elimination from the immune system. In addition, B cell superantigens, e.g. Staphylococcus aureus Cowan strain 1, may contribute to the pathogenesis of autoimmune diseases and malignancies.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5

    基因ID

    921

    NCBI登录号

    NP_055022

    UniProt

    P06127
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