TLR4 抗体 (Biotin)
Quick Overview for TLR4 抗体 (Biotin) (ABIN1106217)
抗原
See all TLR4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应 (详细)
- Species reactivity (tested):Human
-
纯化方法
- Protein G
-
免疫原
- CHO cells expressing chimeric human TLR4/MD-2 fusion protein
-
亚型
- IgG1
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.1 mg/mL
-
缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Store at 2 - 8 °C.
-
-
- TLR4 (Toll-Like Receptor 4 (TLR4))
-
别名
- CD284 / TLR4
-
背景
- TLRs belong to a family of proteins that specifically recognize and sense microbial products. They are highly conserved throughout evolution. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. TLRs identified as type I transmembrane signalling receptors act as innate immune recognition receptors against many pathogens.TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to LPS of Gram-negative bacteria.Synonyms: Toll-like receptor 4
-
NCBI登录号
- NM_138554
-
UniProt
- O00206
-
途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
抗原
-