DC-SIGN/CD209 抗体
Quick Overview for DC-SIGN/CD209 抗体 (ABIN1106051)
抗原
See all DC-SIGN/CD209 (CD209) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts with the C-type lectin, DC-SIGN (CD209), exclusively expressed on human dendritic cells (DC).
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein G
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亚型
- IgG1
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anti-CD209 (CD209) (AA 70-404) antibody
CD209 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD209 (CD209) antibodyCD209 适用: 人 WB, IHC, FACS, IF, ISt, StM 宿主: 小鼠 Monoclonal C209-1781 unconjugated
anti-CD209 (CD209) (AA 270-404) antibodyCD209 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 5C2A6 unconjugated
anti-CD209 (CD209) (AA 297-380) antibodyCD209 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CD209 (CD209) antibodyCD209 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-CD209 (CD209) (AA 1-404) antibodyCD209 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-CD209 (CD209) antibodyCD209 适用: 人 IHC, FACS, IHC (p), IP 宿主: 大鼠 Monoclonal h209 unconjugated
anti-CD209 (CD209) (AA 115-238) antibodyCD209 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD209 (CD209) (AA 265-404) antibodyCD209 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CD209 (CD209) (AA 271-380) antibodyCD209 适用: 人 ELISA, IF, IP 宿主: 小鼠 Monoclonal 3B10 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- DC-SIGN/CD209 (CD209) (CD209)
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别名
- CD209 / DC-SIGN
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背景
- DC are specialized antigen presenting cells and bridge the innate and the adaptive immune system. They provide high levels of costimulation necessary for activation of both naive and antigen-experienced T-cells. Immature DC are capable to migrate to inflammatory sites, capture antigen and process it internally to form MHC-peptide complexes. Following antigen uptake, DC undergo maturation and migrate to lymphoid organs where they can present MHC-peptide complexes to resting T-cells and drive T-cell proliferation. During differentiation and maturation of DC, several phenotypic surface markers are expressed: CD1a, CD4, CD11, CD40, CD86, and HLA-DR. Immature DC predominantly express CCR5 which enables DC to migrate to inflammatory sites, whereas mature DC express high levels of CXCR4, a receptor that facilitates migration to lymphoid organs. DC also express DC-specific, ICAM-3 grabbing, nonintegrin (DC-SIGN), a 44 kDa C-type lectin that binds to the HIV-1 envelope glycoprotein gp120, ICAM-3 on T-cells and ICAM-2 on endothelial cells. HIV virions are able to infect cells expressing CD4 and the chemokine co-receptors CCR5 or CXCR4 and can attach to DC-SIGN to extend virion lifespan. Therefore, DC are candidates for HIV-1 infection. DC-SIGN-ICAM-3 binding is integrin-independent but calcium-dependent and antibodies reactive against DC-SIGN can be used to study DC-SIGN-ICAM3 binding.Synonyms: C-type lectin domain family 4 member L, CLEC4L, DC-SIGN1, DCSIGN, DCSIGN1, Dendritic Cell Marker, Dendritic cell-specific ICAM-3-grabbing non-integrin 1
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基因ID
- 9606
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UniProt
- Q9NNX6
抗原
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