TLR4 抗体
Quick Overview for TLR4 抗体 (ABIN110591)
抗原
See all TLR4 抗体适用
宿主
克隆类型
标记
应用范围
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限制
- 仅限研究用
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状态
- Lyophilized
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储存条件
- 4 °C
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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别名
- TLR4 (Torr-Like Receptor)
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背景
- TLR4 (Toll-like receptor 4) is a mammalian homologue of the Drosophila Toll protein. The human TLR4 is a 799-residue type-1 trans-membrane protein. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of the IL-1 receptor. TLR4 is a receptor for lipopolysaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL-1 receptor for signal transduction that leads to activation of NF-.B.
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
抗原
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