MAP3K14 抗体
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北京 101111
Quick Overview for MAP3K14 抗体 (ABIN110581)
抗原
See all MAP3K14 抗体适用
宿主
克隆类型
标记
应用范围
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限制
- 仅限研究用
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状态
- Lyophilized
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储存条件
- 4 °C
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- MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))
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别名
- NIK (NF-kB-Inducing Kinase)
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背景
- NIK (NF-. B-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-. B activity. NIK, initially isolated from a human B cell cDNA library, contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to I. B phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-. B activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-. B activation.
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途径
- NF-kappaB Signaling, TCR Signaling
抗原
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