TYROBP
适用: 人
ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
宿主: 兔
Polyclonal
unconjugated
限制
仅限研究用
状态
Lyophilized
储存条件
4 °C
抗原
TYROBP
(TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
别名
DAP12
背景
: DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is a disulfide-bonded homodimer. Crosslinking of DAP12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.