c-MYC 抗体 (AA 408-439)
Our Local Distributor
北京 101111
Quick Overview for c-MYC 抗体 (AA 408-439) (ABIN1105578)
抗原
See all c-MYC (MYC) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 408-439
-
特异性
- This antibody recognizes Human c-Myc.
-
纯化方法
- Affinity Chromatography
-
免疫原
- Synthetic peptide corresponding to residues 408-439 of the Human p62c-Myc protein.
-
亚型
- IgG2a
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
溶解方式
- Restore with 1.2 % Sodium Acetate or Neutral PBS
-
浓度
- 0.1 mg/mL
-
缓冲液
- 1.2 % Sodium Acetate, 0.01 mg Sodium Azide, 2 mg BSA
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
-
别名
- C-Myc
-
背景
- C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells,in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.Synonyms: BHLHE39, Class E basic helix-loop-helix protein 39, Myc proto-oncogene protein, Transcription factor p64
-
基因ID
- 4609
-
NCBI登录号
- NP_002458
-
UniProt
- P01106
-
途径
- p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
抗原
-