ARHGEF2 抗体
Quick Overview for ARHGEF2 抗体 (ABIN1105439)
抗原
See all ARHGEF2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- The monoclonal antibody B4/7 recognizes guanine nucleotide exchange factor H1 (GEF-H1).
-
交叉反应 （详细）
- Species reactivity (tested):Human, canine, mouse
-
纯化方法
- Protein G
-
亚型
- IgG1
-
-
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 21-120) antibody
ARHGEF2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (Tyr427) antibodyARHGEF2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (pSer886) antibodyARHGEF2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 小鼠 WB, IP, IF 宿主: 绵羊 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 590-690) antibodyARHGEF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 383-432) antibodyARHGEF2 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 1-959) antibodyARHGEF2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (C-Term) antibodyARHGEF2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.1 mg/mL
-
缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Store at 2 - 8 °C.
-
-
- ARHGEF2 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))
-
别名
- ARHGEF2
-
背景
- GEFH1 is an ~110 kDa protein belonging to the Dbl family of proto-oncogenes. GEF-H1 can activate the small GTPase RhoA, but not Rac1 or Cdc42. Rho family GTPases are central regulators of epithelial tight junctions and the cytoskeleton. GEF-H1 can associate with different cytoskeletal structures, namely microtubules and the actin cytoskeleton. It has also been proposed to mediate crosstalk between the two types of filaments. Localization of GEF-H1 differs between cell types. In MRC-5 fibroblast cells, GEF-H1 localizes to stress fibers. In epithelial cells, GEF-H1 is associated with apical tight junctions and involved in regulating paracellular permeability of small hydrophilic tracers. Furthermore, its subcellular localization changes in mitotic cells, where endogenous GEF-H1 is concentrated at mitotic spindles. GEF-H1 is capable of binding to the F-actin binding junctional adaptor cingulin. Binding to cingulin inhibits GEF-H1 and results in the downregulation of RhoA and inhibition of G1/S phase transition. In low confluent cultured cells, the localization of GEF-H1 is predominantly cytoplasmic. With increasing density of the cells, free GEF-H1 is sequestered at the tight junctions by cingulin. GEF-H1 is part of the signaling pathway connecting epithelial polarity with the cell cycle, and as such involved in oncogenesis.Synonyms: GEF-H1, Guanine nucleotide exchange factor H1, KIAA0651, LFP40, Microtubule-regulated Rho-GEF, Proliferating cell nucleolar antigen p40, Rho guanine nucleotide exchange factor 2
-
基因ID
- 9181
-
NCBI登录号
- NP_001155855
-
UniProt
- Q92974
-
途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
-
