AOC3 抗体
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北京 101111
Quick Overview for AOC3 抗体 (ABIN1105387)
抗原
See all AOC3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The monoclonal antibody 7-88 recognizes mouse Vascular Adhesion Protein-1 (VAP-1) which is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It inhibits migration of granulocytes and monocytes in acute models of inflammation.
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交叉反应 （详细）
- Species reactivity (tested):Mouse.
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纯化方法
- Protein G Chromatography
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免疫原
- Vessels from mouse lymph nodes
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亚型
- IgG2b
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anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 27-190) antibody
AOC3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 613-640) antibodyAOC3 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22029 unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 27-259) antibodyAOC3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 1-763) antibodyAOC3 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (Internal Region) antibodyAOC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 351-450) antibodyAOC3 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4B8 unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人 FACS, Func, IHC (fro) 宿主: 小鼠 Monoclonal 174-5 unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人 WB, ELISA, IHC, IF, FACS, IP, IAC, Inh 宿主: 兔 Chimeric TK8-14 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA
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储存条件
- 4 °C
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储存方法
- Store undiluted at 2-8 °C.
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- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
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别名
- AOC3 / VAP1
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背景
- VAP-1 is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is expressed in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end-products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. In white adipose tissue of obese and diabetic db-/- mice increased expression of VAP-1 has been observed suggesting that it contributes to the arthrosclerosis and vascular dysfunction observed in these diseases. Moreover, inhibition of VAP-1reduced the accumulation of myeloid cells into tumors and attenuates tumor growth.Synonyms: Copper amine oxidase, HPAO, Membrane primary amine oxidase, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1
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基因ID
- 11754
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NCBI登录号
- NP_033805
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UniProt
- O70423
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途径
- Feeding Behaviour
抗原
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