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KEAP1 抗体 (AA 380-624)

KEAP1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7G4B10 unconjugated
产品编号 ABIN1098141
发货至: 中国
  • 抗原 See all KEAP1 抗体
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    抗原表位
    • 15
    • 14
    • 13
    • 10
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 380-624
    适用
    • 86
    • 63
    • 38
    • 20
    • 17
    • 7
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    宿主
    • 88
    • 8
    • 1
    小鼠
    克隆类型
    • 86
    • 11
    单克隆
    标记
    • 50
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KEAP1 antibody is un-conjugated
    应用范围
    • 81
    • 41
    • 36
    • 25
    • 25
    • 15
    • 12
    • 9
    • 8
    • 6
    • 5
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    原理
    KEAP1 Antibody
    纯化方法
    Purified antibody
    免疫原
    Purified recombinant fragment of human KEAP1 (AA: 380-624 ) expressed in E. Coli.
    克隆位点
    7G4B10
    亚型
    IgG1
    Top Product
    Discover our top product KEAP1 Primary Antibody
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: "Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome." in: Epigenetics, Vol. 6, Issue 3, pp. 317-25, (2011) (PubMed).

    Niture, Jaiswal: "INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis." in: Cell death and differentiation, Vol. 18, Issue 3, pp. 439-51, (2011) (PubMed).

  • 抗原
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    别名
    KEAP1 (KEAP1 产品)
    背景
    This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

    分子量
    69.7 kDa
    基因ID
    9817
    UniProt
    Q14145
    途径
    Maintenance of Protein Location
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