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KEAP1 抗体 (AA 380-624)

This anti-KEAP1 antibody is a 小鼠 单克隆 antibody detecting KEAP1 in ELISA, ICC 和 FACS. Suitable for 人 和 小鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN1098137
发货至: 中国

Quick Overview for KEAP1 抗体 (AA 380-624) (ABIN1098137)

抗原

See all KEAP1 抗体
KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

适用

  • 92
  • 64
  • 40
  • 23
  • 19
  • 8
  • 7
  • 5
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
人, 小鼠

宿主

  • 93
  • 9
  • 1
小鼠

克隆类型

  • 91
  • 12
单克隆

标记

  • 55
  • 8
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This KEAP1 antibody is un-conjugated

应用范围

  • 87
  • 42
  • 40
  • 26
  • 26
  • 16
  • 12
  • 12
  • 9
  • 6
  • 5
  • 2
  • 1
  • 1
ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

克隆位点

1F10B6
  • 抗原表位

    • 15
    • 15
    • 13
    • 12
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 380-624

    原理

    KEAP1 Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human KEAP1 (AA: 380-624) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Kim, You, Lee, Ahn, Seong, Hwang: "Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation." in: Cellular signalling, Vol. 22, Issue 11, pp. 1645-54, (2010) (PubMed).

    Zhang, Singh, Yegnasubramanian, Esopi, Kombairaju, Bodas, Wu, Bova, Biswal: "Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth." in: Molecular cancer therapeutics, Vol. 9, Issue 2, pp. 336-46, (2010) (PubMed).

  • 抗原

    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

    别名

    KEAP1

    背景

    This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.





    分子量

    69.7 kDa

    基因ID

    9817

    UniProt

    Q14145

    途径

    Maintenance of Protein Location
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