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KEAP1 抗体 (AA 380-624)

KEAP1 适用: 人, 小鼠 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1F10B6 unconjugated
产品编号 ABIN1098137
发货至: 中国
  • 抗原 See all KEAP1 抗体
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    抗原表位
    • 15
    • 15
    • 13
    • 12
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 380-624
    适用
    • 92
    • 64
    • 40
    • 23
    • 19
    • 8
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    人, 小鼠
    宿主
    • 93
    • 9
    • 1
    小鼠
    克隆类型
    • 91
    • 12
    单克隆
    标记
    • 55
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KEAP1 antibody is un-conjugated
    应用范围
    • 87
    • 42
    • 40
    • 26
    • 26
    • 16
    • 12
    • 11
    • 10
    • 6
    • 5
    • 2
    • 1
    • 1
    ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
    原理
    KEAP1 Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human KEAP1 (AA: 380-624) expressed in E. Coli.
    克隆位点
    1F10B6
    亚型
    IgG1
    Top Product
    Discover our top product KEAP1 Primary Antibody
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/50

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Kim, You, Lee, Ahn, Seong, Hwang: "Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation." in: Cellular signalling, Vol. 22, Issue 11, pp. 1645-54, (2010) (PubMed).

    Zhang, Singh, Yegnasubramanian, Esopi, Kombairaju, Bodas, Wu, Bova, Biswal: "Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth." in: Molecular cancer therapeutics, Vol. 9, Issue 2, pp. 336-46, (2010) (PubMed).

  • 抗原
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    别名
    KEAP1 (KEAP1 产品)
    背景
    This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.





    分子量
    69.7 kDa
    基因ID
    9817
    UniProt
    Q14145
    途径
    Maintenance of Protein Location
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