HAS2 抗体 (AA 67-170)
(2 references)Quick Overview for HAS2 抗体 (AA 67-170) (ABIN1098124)
抗原
See all HAS2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 67-170
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原理
- HAS2 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.
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亚型
- IgG1
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anti-Hyaluronan Synthase 2 (HAS2) (AA 138-166) antibody
HAS2 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22492 unconjugated
anti-Hyaluronan Synthase 2 (HAS2) antibodyHAS2 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 2 (HAS2) (AA 70-359) antibodyHAS2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 2 (HAS2) antibodyHAS2 适用: 人 ELISA, WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 40000000 unconjugated
anti-Hyaluronan Synthase 2 (HAS2) (AA 67-185) antibodyHAS2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
ICC: 1/100 - 1/500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." in: Cancer research, Vol. 72, Issue 2, pp. 537-47, (2012) (PubMed).
: "Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1." in: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33632-40, (2011) (PubMed).
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: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." in: Cancer research, Vol. 72, Issue 2, pp. 537-47, (2012) (PubMed).
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- HAS2 (Hyaluronan Synthase 2 (HAS2))
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别名
- HAS2
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背景
- Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
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分子量
- 63.5 kDa
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UniProt
- Q92819
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途径
- Glycosaminoglycan Metabolic Process
抗原
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