The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Jul 2008].
Zhang, Rosenberg: "Diversifying selection of the tumor-growth promoter angiogenin in primate evolution." in: Molecular biology and evolution, Vol. 19, Issue 4, pp. 438-45, (2002) (PubMed).
Kurachi, Davie, Strydom, Riordan, Vallee: "Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor." in: Biochemistry, Vol. 24, Issue 20, pp. 5494-9, (1986) (PubMed).
Aliases for Angiogenin 蛋白
angiogenin (ANG) 蛋白 angiogenin, ribonuclease, RNase A family, 5 (Ang) 蛋白 angiogenin, ribonuclease, RNase A family, 5 (ANG) 蛋白 angiogenin (Ang) 蛋白 ribonuclease A family member k6 (RNASE6) 蛋白 AI385586 蛋白 ALS9 蛋白 ANG 蛋白 Ang1 蛋白 ANG1 蛋白 HEL168 蛋白 RNASE4 蛋白 RNASE5 蛋白 Rnase5 蛋白 Rnase5a 蛋白