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抗Human CPT1A 抗体:
抗Mouse (Murine) CPT1A 抗体:
抗Rat (Rattus) CPT1A 抗体:
Human Polyclonal CPT1A Primary Antibody for IHC (p), IHC - ABIN251677
Rayner, Esau, Hussain, McDaniel, Marshall, van Gils, Ray, Sheedy, Goedeke, Liu, Khatsenko, Kaimal, Lees, Fernandez-Hernando, Fisher, Temel, Moore: Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. in Nature 2011
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Cow (Bovine) Polyclonal CPT1A Primary Antibody for IHC, WB - ABIN2782010
Roomets, Kivelä, Tyni: Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects. in Investigative ophthalmology & visual science 2008
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Human Polyclonal CPT1A Primary Antibody for IF (p), IHC (p) - ABIN677018
Fan, Wang, Ge, Wang, Li, Kong: Betaine supplementation protects against high-fructose-induced renal injury in rats. in The Journal of nutritional biochemistry 2014
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Mouse (Murine) Polyclonal CPT1A Primary Antibody for ELISA - ABIN451728
Mazzarelli, Pucci, Bonanno, Sesti, Calvani, Spagnoli: Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? in Cancer biology & therapy 2008
Human Polyclonal CPT1A Primary Antibody for WB - ABIN658583
Shi, Wang, Yang, Xie, Zhu: IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet. in FEBS open bio 2017
the expression of CPT1A was higher in oestrogen receptor (ER)-positive, compared to ER-negative tumours and cell lines. Importantly, overexpression of CPT1A significantly decreased the proliferation and wound healing migration rates of MDA-MB231 breast cancer cells, compared to basal expression control
High expression level of CPT1A is associated with breast cancer.
The rs80356779, a p.Pro479Leu variant in CPT1A, was highly significantly associated with a range of fatty acid metabolism measures in a population-based sample from Greenland.
associations between methylation in CPT1A and lipoprotein measures highlight the epigenetic role of this gene in metabolic dysfunction.
Homozygosity for the arctic variant is associated with increased risk of infant mortality, which may be mediated in part by an increase in infectious disease risk. Further studies are needed to determine whether the association we report represents a causal association between the CPT1A arctic variant and infectious disease-specific mortality
We provide evidence that the downregulation of hsa (显示 CD24 抗体)-miR (显示 MLXIP 抗体)-124-3p, hsa (显示 CD24 抗体)-miR (显示 MLXIP 抗体)-129-5p and hsa (显示 CD24 抗体)-miR (显示 MLXIP 抗体)-378 induced an increase in both expression and activity of CPT1A, CACT (显示 SLC25A20 抗体) and CrAT (显示 CRAT 抗体) in malignant prostate cells.
The recent findings and the current understanding of fatty acid oxidation and CPT1A in cancer have been summarized thus providing theoretical basis for this enzyme as an emerging potential molecular target in cancer therapeutic intervention. (Review)
Methylation of a CpG site in CPT1A is associated with circulating adiponectin levels, likely in an obesity-dependent manner, in three population-based adult cohorts of European descent.
Furthermore, given the already low abundance of Cpt1b (显示 CPT1B 抗体) in white adipose tissue, it is unlikely that decreases in its expression can quantitatively decrease whole body energy expenditure enough to contribute to an obese phenotype.
Data show that in the absence of indoleamine 2,3-dioxygenase (IDO (显示 IDO1 抗体)) inhibition, fatty acid oxidation increased along with increased activity of carnitine palmitoyltransferase I (CPT1).
acetate is the primary product of hepatic mitochondrial beta-oxidation in Sus scrofa and that regulation during early development is mediated primarily via kinetic modulation of CPT I (显示 CPT1B 抗体)
This study evaluated the effects of nonesterified fatty acids and glucose on carnitine palmitoyltransferase-I (CPT-I) mRNA expression in cultured bovine hepatocytes using real-time reverse transcription polymerase chain reaction and ELISA methods.
It was conclude that suppression of CPT (显示 DHDDS 抗体) activity by positive energy balance appears to be specific for the liver in mid-lactating dairy cows.
Alogliptin increased hepatic mRNA expression levels associated with fatty acid oxidation. In addition, the results of the present study suggested that ALO (显示 LMX1B 抗体) promotes CPT1a expression via Thr172 phosphorylation of AMPKalpha (显示 GRK4 抗体).
beneficial effects of muscle CPT1mt expression suggest that a direct modulation of the malonyl-CoA/CPT1 partnership in skeletal muscle could represent a potential strategy to prevent obesity-induced insulin (显示 INS 抗体) resistance
The data suggest that AMPK (显示 PRKAA1 抗体) is not required for the regulation of the intermediate filament interaction with CPT-I during exercise.
these results demonstrated that L-carnitine ameliorated liver inflammation and serum pro-inflammatory markers in cancer cachexia through regulating CPT I-dependent PPARg (显示 PPARG 抗体) signaling
-Carnitine exerts its ameliorative effects in cancer cachexia in association with the PPAR-gamma (显示 PPARG 抗体) signaling pathway.
Data show that peroxisome-proliferator-activated receptor beta (显示 PPARD 抗体)/delta (PPARbeta (显示 PPARD 抗体)/delta) activation restored the lipid-induced endothelial dysfunction by up-regulation of carnitine palmitoyltransferase)-1 (CPT-1).
Our results indicated that exercise-induced CPT1b (显示 CPT1B 抗体) expression was at least in part mediated by HDAC5 (显示 HDAC5 抗体)/MEF2A (显示 MEF2A 抗体) interaction.
an environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A
miR (显示 MLXIP 抗体)-370 acting via miR (显示 MLXIP 抗体)-122 may have a causative role in the accumulation of hepatic triglycerides by modulating initially the expression of SREBP-1c (显示 SREBF1 抗体), DGAT2 (显示 DGAT2 抗体), and Cpt1alpha.
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
carnitine palmitoyltransferase 1A (liver)
, carnitine O-palmitoyltransferase 1, liver isoform-like
, CPT I
, carnitine O-palmitoyltransferase 1, liver isoform
, carnitine O-palmitoyltransferase I, liver isoform
, carnitine palmitoyltransferase I, liver
, carnitine palmitoyl transferase I liver isoform
, liver type carnitine palmitoyltransferase I
, mitochondrial carnitine palmitoyltransferase 1A
, carnitine palmitoyltransferase 1A
, carnitine palmitoyltransferase I
, carnitine palmitoyl transferase I isoform
, L-CPT I
, carnitine palmitoyltransferase 1, liver
, Carnitine palmitoyltransferase 1 alpha, liver isoform