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CPT1A 抗体 (Middle Region)

CPT1A 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 绵羊, 斑马鱼, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2782010
发货至: 中国
  • 抗原 See all CPT1A 抗体
    CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))
    抗原表位
    • 11
    • 8
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 47
    • 17
    • 15
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 马, 兔, 绵羊, 斑马鱼, 犬, 豚鼠
    宿主
    • 60
    • 4
    • 2
    克隆类型
    • 61
    • 5
    多克隆
    标记
    • 31
    • 14
    • 10
    • 5
    • 3
    • 3
    This CPT1A antibody is un-conjugated
    应用范围
    • 61
    • 40
    • 22
    • 7
    • 7
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    LSTSQTPQQQ VELFDLENNP EYVSSGGGFG PVADDGYGVS YILVGENLIN
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    产品特性
    This is a rabbit polyclonal antibody against CPT1A. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human CPT1A
    Top Product
    Discover our top product CPT1A Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 756 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Piemontese, Cerchia, Laghezza, Ziccardi, Sblano, Tortorella, Iacobazzi, Infantino, Convertini, Dal Piaz, Lupo, Colantuoni, Lavecchia, Loiodice: "New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity." in: European journal of medicinal chemistry, Vol. 127, pp. 379-397, (2017) (PubMed).

    Convertini, Menga, Andria, Scala, Santarsiero, Castiglione Morelli, Iacobazzi, Infantino: "The contribution of the citrate pathway to oxidative stress in Down syndrome." in: Immunology, Vol. 149, Issue 4, pp. 423-431, (2016) (PubMed).

    Laghezza, Pochetti, Lavecchia, Fracchiolla, Faliti, Piemontese, Di Giovanni, Iacobazzi, Infantino, Montanari, Capelli, Tortorella, Loiodice: "New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor ?/? dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression." in: Journal of medicinal chemistry, Vol. 56, Issue 1, pp. 60-72, (2013) (PubMed).

  • 抗原
    CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))
    别名
    CPT1A (CPT1A 产品)
    别名
    MGC53498 antibody, CPT1 antibody, CPT1-L antibody, L-CPT1 antibody, L-CPTI antibody, si:dkey-56p7.8 antibody, C730027G07 antibody, CPTI antibody, Cpt1 antibody, CPT-Ia antibody, carnitine palmitoyltransferase 1A (liver) L homeolog antibody, carnitine palmitoyltransferase 1A antibody, carnitine palmitoyltransferase 1A (liver) antibody, carnitine palmitoyltransferase 1Aa (liver) antibody, carnitine palmitoyltransferase 1a, liver antibody, cpt1a.L antibody, CPT1A antibody, cpt1a antibody, cpt1aa antibody, Cpt1a antibody
    背景
    The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: CPT1, CPT1-L, L-CPT1
    Protein Interaction Partner: UBC, SUMO2, LGR4, RNF2, FBXO6, PARK2, LYN, CLN3, HDAC11, KBTBD7, NPDC1, HSPA5, NR4A1, CYBA, CLIC1, SNRNP200, ERLIN1, TOMM40, EIF3C, PCBP1, NDUFV1, NDUFS1, NDUFA2, LPP, CPS1, ATP6V1C1, RHOA, PCK1, BCL2,
    Protein Size: 756
    分子量
    86 kDa
    基因ID
    1374
    NCBI登录号
    NM_001031847, NP_001027017
    UniProt
    P50416
    途径
    AMPK Signaling, Regulation of Lipid Metabolism by PPARalpha, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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