The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011].
Quiñones-Lombraña, Ferguson, Hageman Blair, Kalabus, Redzematovic, Blanco: "Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome." in: Pharmaceutical research, Vol. 31, Issue 7, pp. 1644-55, (2014) (PubMed).
Aliases for AKR7A2 抗体
aldo-keto reductase family 7 member A2 (AKR7A2) 抗体 aldo-keto reductase family 7, member A2 (Akr7a2) 抗体 aldo-keto reductase family 7, member A2 L homeolog (akr7a2.L) 抗体 AFAR 抗体 AFAR1 抗体 AFB1-AR1 抗体 Aiar 抗体 AKR7 抗体 akr7a2 抗体