AKR1C2 抗体
(Aldo-keto Reductase Family 1, Member C2 (AKR1C2))
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
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Latest Publications for our AKR1C2 抗体
: "Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 239-49, (2011) (PubMed).: "Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 217-26, (2011) (PubMed).
: "Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 36, Issue 6, pp. 991-4, (2008) (PubMed).
: "Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis." in: Toxicology, Vol. 244, Issue 2-3, pp. 257-70, (2008) (PubMed).
Aliases for AKR1C2 抗体
aldo-keto reductase family 1 member C2 (AKR1C2) 抗体aldo-keto reductase family 1, member C2 (Akr1c2) 抗体
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