The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008].
Schillace, Andrews, Liberty, Davey, Carr: "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 4, pp. 1590-9, (2002) (PubMed).
Jicha, Weaver, Lane, Vianna, Kress, Rockwood, Davies: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, (1999) (PubMed).
Coghlan, Perrino, Howard, Langeberg, Hicks, Gallatin, Scott: "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein." in: Science (New York, N.Y.), Vol. 267, Issue 5194, pp. 108-11, (1995) (PubMed).
Carr, Stofko-Hahn, Fraser, Cone, Scott: "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79." in: The Journal of biological chemistry, Vol. 267, Issue 24, pp. 16816-23, (1992) (PubMed).
Aliases for AKAP5 抗体
A kinase (PRKA) anchor protein 5 (AKAP5) 抗体 A-kinase anchoring protein 5 (AKAP5) 抗体 A kinase (PRKA) anchor protein 5 (Akap5) 抗体 A-kinase anchoring protein 5 (Akap5) 抗体 3526401B18Rik 抗体 AKAP 抗体 AKAP-5 抗体 AKAP5 抗体 AKAP75 抗体 AKAP79 抗体 Akap79 抗体 AKAP 150 抗体 AKAP150 抗体 BB098886 抗体 Gm258 抗体 H21 抗体 P75 抗体 P150 抗体